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Presence of VZV and HSV-1 DNA in Human Nodose and Celiac Ganglia

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Abstract

Polymerase chain reaction (PCR) revealed herpes simplex virus (HSV) and varicella zoster virus (VZV) DNA in human nodose and celiac ganglia. This is the first detection of VZV DNA in ganglia of the human autonomic nervous system. The ability of reactivated VZV to produce serious, sometimes fatal neurological disease in the absence of rash, raises the possibility that VZV reactivation from autonomic ganglia might be involved in visceral disease.

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Authors and Affiliations

  1. Department of Neurology, University of Colorado Health Sciences Center, Denver, Colorado, USA

    Donald H. Gilden, John Smith, Mary Wellish, James J. Laguardia, Randall J. Cohrs & Ravi Mahalingam

  2. Department of Microbiology, University of Colorado Health Sciences Center, Denver, Colorado, USA

    Donald H. Gilden

  3. Infectious Diseases, Merck Research Laboratories, Blue Bell, Pennsylvania, USA

    Richard Gesser

Authors
  1. Donald H. Gilden
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  2. Richard Gesser
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  3. John Smith
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  4. Mary Wellish
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  5. James J. Laguardia
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  6. Randall J. Cohrs
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  7. Ravi Mahalingam
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Correspondence to Donald H. Gilden.

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Gilden, D.H., Gesser, R., Smith, J. et al. Presence of VZV and HSV-1 DNA in Human Nodose and Celiac Ganglia. Virus Genes 23, 145–147 (2001). https://doi.org/10.1023/A:1011883919058

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  • DOI: https://doi.org/10.1023/A:1011883919058

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