Abstract
Two types of chitosan oligosaccharides (COS), COS I (1-kDa < MW < 3-kDa) and COS II (3-kDa < MW < 5-kDa), were tested for antimutagenic activities against chemical mutagens using Umu gene expression, Ames, and Bacillus subtilis Rec mutagenicity tests. At the highest chitosan oligosaccharide dose (1 mg) tested, mutagenic activity of indirect-acting mutagen was inhibited by ∼50% in the Umu gene expression system and in the Ames test. Chitosan oligosaccharide (0.01, 0.1 and 1 mg) also suppressed 4-nitroquinoline-N-oxide (NQO)-induced mutagenicity in the B. subtilis Rec− assay.
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Nam, KS., Choi, YR. & Shon, YH. Evaluation of the antimutagenic potential of chitosan oligosaccharide: Rec, Ames and Umu tests. Biotechnology Letters 23, 971–975 (2001). https://doi.org/10.1023/A:1010519224254
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DOI: https://doi.org/10.1023/A:1010519224254