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G Proteins in Heart Disease

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Abstract

Heterotrimeric G proteins are the signal transducers for seven transmembrane spanning receptors, enabling receptor activation of individual downstream signaling pathways. Modified expression or activity of G proteins and their downstream effectors is postulated to play a role in cardiac hypertrophy and heart failure. This paper reviews the evidence for and against a pathologic role for G proteins in cardiac disease.

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Authors and Affiliations

  1. Department of Medicine, University of Cincinnati Medical Center, Cincinnati, Ohio

    Gerald W. Dorn II

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Dorn, G.W. G Proteins in Heart Disease. Heart Fail Rev 4, 303–310 (1999). https://doi.org/10.1023/A:1009895301426

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  • DOI: https://doi.org/10.1023/A:1009895301426

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