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Mesenteric Cyclooxygenase Products After Combined Antihypertensive Treatment in Uninephrectomized SHRs

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Abstract

Unilateral nephrectomy in the spontaneously hypertensive rat (SHR) does not produce any change in blood pressure but does induce humoral alterations that might influence the antihypertensive action of some drugs. In this study, the antihypertensive effect of treatment (5 weeks) with placebo (control), verapamil, trandolapril, or their combination (verapamil plus trandolapril) was investigated in SHRs with half renal mass ablation, regarding the structure and function of small mesenteric arteries. Arterial pressure was followed during the period of treatment. Trandolapril and veratran returned pressure to normal, while verapamil was ineffective. Statistically significant differences in the parameters of vessel structure were not observed among groups; thus, the alterations in functionality cannot be attributed to morphologic changes. The noradrenaline-induced contraction was reduced similarly by the three treatments as compared to controls. This difference involved a higher participation of nitric oxide in the trandolapril group, while in the verapamil group the origin of the difference might be due to the abolishment of a cyclooxygenase product. Veratran retained both effects. Acetylcholine-evoked relaxation of vessels precontracted with noradrenaline was improved with treatments versus controls. The abolishment of a contracting prostanoid or an NO scavenger from the cyclooxygenase pathway, due to the treatments implemented, is probably the cause of this.

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References

  1. Díez J, Coca A, De Teresa E, Laviades C, Ló pez-Sendó n JL, Tamargo J, eds. Remodelado y Reparació n Cardiovascular. Madrid: Ed. Ergon, S.A., 1995.

    Google Scholar 

  2. Marín J. Mechanisms involved in the increased vascular resistance in hypertension. J Autonom Pharmacol 1993;13: 127-176.

    Google Scholar 

  3. Packer CS. Changes in arterial smooth muscle contractility, contractile proteins, and arterial wall structure in spontaneous hypertension. Proc Soc Exp Biol Med 1994;207(2): 148-174.

    Google Scholar 

  4. Korner PI. Causal and homeostatic factors in hypertension. Clin Sci 1982;62:15-26s.

    Google Scholar 

  5. Folkow B. Early structural changes in hypertension: pathophysiology and clinical concequences. J Cardiovasc Pharmacol 1993;22(Suppl. 1):S1-S6.

    Google Scholar 

  6. Nava E, Lüscher TF. Endothelium-derived vasoactive factors in hypertension: nitric oxide and endothelin. J Hypertens 1995;13(Suppl. 2):S39-S48.

    Google Scholar 

  7. Karlström G, Folkow B, Gothberg G. The humoral renal antihypertensive system: nervous and haemodynamic effects in normotensive and unclipped renal hypertensive rats. Am J Med Sci 1988;31(4):258-262.

    Google Scholar 

  8. Karlström G, Arnman V, Bergstrom G, et al. Do angiotensin converting enzyme inhibitors lower blood pressure in the rat partly via the humorally mediated antihypertensive system of the renal medulla? J Hypertens 1990;8:501-513.

    Google Scholar 

  9. Lee MRKW. Vascular changes at the prehypertensive phase in the mesenteric arteries from the spontaneously hypertensive rats. Blood Vessels 1983;22:105-126.

    Google Scholar 

  10. Griffin KA, Bidani AK, Picken M, et al. Prostaglandins do not mediate impaired autoregulation or increased renin secretion in remnant rat kidneys. Am J Physiol 1992;263 (6):F1057-F1062.

    Google Scholar 

  11. Bidani AK, Griffin KA, Plott W, et al. Renal ablation acutely transforms "benign" hypertension to "malignant" nephrosclerosis in hypertensive rats. Hypertension 1994;24(3): 309-316.

    Google Scholar 

  12. Flores O, MacLaughlin M, Gallego B, et al. Factores que desencadenan glomerulosclerosis después de la reducció n de la masa renal. Nefrología 1996;16(Suppl. 3):14-21.

    Google Scholar 

  13. Banfic H, Kukolja S. Plasma from uninephrectomized rats stimulates production of inositol trisphosphate and of inositol tetrakisphosphate in renal cortical slices. Biochem J 1988;255(2):671-676.

    Google Scholar 

  14. Esbrit P, García-Ocañ a A, García-Carnero R, et al. Biological properties of a renotropic protein present in plasma of uninephrectomized rats. Renal Physiol Biochem 1991;14(6): 224-235.

    Google Scholar 

  15. Ferreire U, Claro JA, Rodrigues-Netto N Jr, et al. Functional and histologic alterations in growing solitary rat kidney as a result of extracorporeal shockwaves. J Endourol 1995;9(1):45-49.

    Google Scholar 

  16. Ream SG, Villareal D, Wu Z, et al. Glomerular function and structure in the sodium-replete and sodium-deplete uninephrectomized spontaneously hypertensive rat: effect of blood pressure reduction, glomerular structure, and blood pressure reduction. Am J Med Sci 1995;309(1):35-42.

    Google Scholar 

  17. Pollock CA, Nobes MS, Gyory AZ, et al. Transferable circulating factors and epithelial sodium transport after unilateral nephrectomy in the rat. J Physiol 1996;490:257-264.

    Google Scholar 

  18. Valentin JP. Plasma concentration of atrial natriuretic peptide after acute reduction in functioning renal mass in the rat. Can J Physiol Pharmacol 1997;75(2):153-157.

    Google Scholar 

  19. Ló pez-Hernández FJ, Flores O, Ló pez-Novoa JM, et al. Antihypertensive action of trandolapril and verapamil in spontaneously hypertensive rats after unilateral nephrectomy. J Cardiovasc Pharmacol 1998;32(2):284-290.

    Google Scholar 

  20. Byrom FB, Wilson CA. Aplethysmographic method of measuring blood pressure in the rat. J Physiol 1938;93:301-304.

    Google Scholar 

  21. Bennet MA, Watt PAC, Thurston H. Endothelium-dependent modulation of resistance vessel contraction: studies with NG-nitro-L-arginine. J Cardiovasc Pharmacol 1992;107: 616-621.

    Google Scholar 

  22. Parsons SJW, Hill A, Waldron GJ, et al. The relative importance of nitric oxide and nitric oxide-independent mechanisms in acetylcholine-evoked dilation of the rat mesenteric bed. Br J Pharmacol 1994;113:1275-1280.

    Google Scholar 

  23. Wu XC, Michael J, Richards NT. Interdependence of contractile responses of rat small mesenteric arteries on nitric oxide and cyclo-oxygenase and lipoxygenase products of arachidonic acid. Br J Pharmacol 1994;112:360-368.

    Google Scholar 

  24. Lüscher TF, Aarthus LL, Vanhoutte PM. Indomethacin improves the impaired endothelium-dependent relaxations in small mesenteric arteries of the spontaneously hypertensive rat. Am J Hypertens 1990;3(1):55-58.

    Google Scholar 

  25. Li J, Bukosky RD. Endothelium-dependent relaxation of mesenteric resistance arteries is not impaired under all conditions. Circ Res 1993;72(2):290-296.

    Google Scholar 

  26. Takase H, Dohi Y, Kojima M, et al. Changes in the endothelial cyclooxygenase pathway in resistance arteries of spontaneously hypertensive rats. J Cardiovasc Pharmacol 1994; 23(2):326-330.

    Google Scholar 

  27. Wuorela H, Arvola P, Kahonen M, et al. Arterial smooth muscle responses in adult and moderately aged spontaneously hypertensive rats. Pharmacol Toxicol 1994;74(3): 167-173.

    Google Scholar 

  28. Cuevas P, García-Calvo M, Carceller F, et al. Correction of hypertension by normalization of endothelial levels of fibroblast growth factor and nitric oxide synthase in spontaneously hypertensive rats. Proc Natl Acad Sci USA 1996; 93(21):11996-12001.

    Google Scholar 

  29. Wu X, Makynen H, Kahonen M, et al. Mesenteric arterial function in vitro in three models of experimental hypertension. J Hypertens 1996;14(3):365-372.

    Google Scholar 

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Authors and Affiliations

  1. Departamento de Fisiología y Farmacología, Facultad de Farmacia, Universidad de Salamanca, Campus Miguel de Unamuno, 37007, Salamanca, Spain

    Francisco J. López-Hernández, María J. Montero & Rosalía Carrón

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  1. Francisco J. López-Hernández
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  2. María J. Montero
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  3. Rosalía Carrón
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López-Hernández, F.J., Montero, M.J. & Carrón, R. Mesenteric Cyclooxygenase Products After Combined Antihypertensive Treatment in Uninephrectomized SHRs. Cardiovasc Drugs Ther 14, 41–48 (2000). https://doi.org/10.1023/A:1007839104402

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