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Multiresistant non-fermentative Gram-negative bacteria in cystic fibrosis patients: the results of an Italian multicenter study

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Abstract

We carried out an epidemiological study on 2717 patients seen on a regular basis at Italian Cystic Fibrosis Centers with the aim of defining the prevalence of multiresistant Gram-negative strains in Italy. We found 272 multiresistant strains out of 1560 Gram-negative strains isolated in 1012 Italian cystic fibrosis patients. From our results in Italian cystic fibrosis patients we may conclude: (1)the beta-lactam antibiotics are moderately active; ceftazidime is the most efficacious even if 59.9% of multiresistant strains are not sensitive to this drug; (2)the aminoglycosides are poorly efficacious; 93% of multiresistant strains are resistant in vitro to tobramycin; and (3)the quinolones, notwithstanding their relatively recent introduction into clinical practice, have very poor activity against multiresistant strains, 89.7% of which are not sensitive.

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Authors and Affiliations

  1. Cystic Fibrosis Center, Meyer Hospital, University of Florence, Italy

    Giovanni Taccetti, Silvia Campana & Lore Marianelli

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  1. Giovanni Taccetti
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  2. Silvia Campana
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  3. Lore Marianelli
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Taccetti, G., Campana, S. & Marianelli, L. Multiresistant non-fermentative Gram-negative bacteria in cystic fibrosis patients: the results of an Italian multicenter study. Eur J Epidemiol 15, 85–88 (1999). https://doi.org/10.1023/A:1007504524034

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