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Host organism defense by a peptide-polysaccharide extracted from the fungus Sporothrix schenckii

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Abstract

A peptide-polysaccharide, a peptide-rhamnomannan, was isolated from the pathogenic yeast form of the fungus Sporothrix schenckii. This substance, which may play a role in fungal virulence, was tested in an animal model of systemic disease, and depression of the immune response was observed in the animals between the 4th and 6th week of infection. Concomitantly, this compound showed mitogenic activity when challenged with normal lymphocytes and was also found to be involved in the inflammatory response. These results provide further information for the understanding of fungal implantation in tissues and of the pathogenicity of this systemic mycosis.

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Authors and Affiliations

  1. Departamento de Análises Clínicas, Faculdade de Ciências Farmacêuticas de Araraquara, Universidade Paulista Júlio Mesquita Filho, Araraquara, SP, Brazil

    Iracilda Zeppone Carlos & Marisa Campos Polesi Placeres

  2. Departamento de Microbiologia e Parasitologia, Instituto Biomédico, Universidade Federal Fluminense, Niterói, RJ, Brasil

    Diana Bridon da graça Sgarbi

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  1. Iracilda Zeppone Carlos
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  2. Diana Bridon da graça Sgarbi
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  3. Marisa Campos Polesi Placeres
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Carlos, I.Z., Sgarbi, D.B.d.g. & Placeres, M.C.P. Host organism defense by a peptide-polysaccharide extracted from the fungus Sporothrix schenckii. Mycopathologia 144, 9–14 (1998). https://doi.org/10.1023/A:1006964516334

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