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BMIPP imaging to assess functional outcome in patients with acute and chronic left ventricular dysfunction

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Abstract

Assessment of myocardial viability is an important clinical issue for patient management during the acute and chronic stages of myocardial infarction. BMIPP (15-(p-iodophenyl)-3-(R,S)-methyl pentadecanoic acid) is a free fatty acid analogue which is trapped in the myocardium, thus permitting for metabolic imaging with single photon emission computerized tomography (SPECT). Less BMIPP than flow tracers that may be observed in the areas of infarction, may reflect the metabolic shift from fatty acid to glucose utilization in ischaemic myocardium. In this sense, the combined imaging of BMIPP and a flow tracer with SPECT may provide similar and important information as fluoro-18 deoxyglucose (FDG) and positron emission tomography (PET) regarding the assessment of myocardial viability. The purpose of this article is to review the clinical impact of BMIPP in patients with acute and with chronic left ventricular dysfunction for the identification of jeopardized but viable myocardium and the prediction of the functional outcome.

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References

  1. Pierard L, De Landsheere C, Berthe C, Rigo P, Kulbertus H. Identification of viable myocardium by echocardiography during dobutamine infusion in patients with myocardial infarction after thrombolytic therapy: comparison with positron emission tomography. J Am Coll Cardiol 1990; 15: 1021-1031.

    Google Scholar 

  2. Udelson JE, Coleman PS, Metherall J, et al. Predicting recovery of severe regional ventricular dysfunction: comparison between resting scintigraphy with Tl-201 and Tc-99m sestamibi. Circulation 1994: 89: 2552-2561.

    Google Scholar 

  3. Altehoefer C, vom Dahl J, Biedermann M, et al. Significance of defect severity in Tc-99m MIBI SPECT at rest to assess myocardial viability: comparison with fluorine-18-FDG PET. Eur J Nucl Med 1994; 35: 569-574.

    Google Scholar 

  4. Knapp FF Jr, Kropp J, Franken PR, et al. Pharmacokinetics of radioiodinated fatty acid myocardial imaging agents in animal models and human studies. QJ Nucl Med 1996; 40: 252-269.

    Google Scholar 

  5. Knapp FF Jr, Ambrose KR, Goodman MM. New radioiodinated methyl branched fatty acids for cardiac studies. Eur J Nucl Med 1986; 12: S39-S44.

    Google Scholar 

  6. Bianco JA, Elmaleh DR, Leppo JA. Effect of glucose and insulin infusion on the myocardial extraction of radioiodinated methyl-substituted fatty acid. Eur J Nucl Med 1986; 12: 120-124.

    Google Scholar 

  7. Fujibayashi Y, Yonekura Y, Takemura Y, et al. Myocardial accumulation of iodinated beta-methyl branched fatty acid analogue, iodine-125-15-(p-iodophenyl)-3-(R,S) methyl pentadecanoic acid (BMIPP) in relation to ATP concentration. J Nucl Med 1990; 31: 1818-1822.

    Google Scholar 

  8. Matsunari I, Saga T, Taki J, et al. Kinetics of iodine-123 BMIPP in patients with prior myocardial infarction: assessment with dynamic rest and stress images compared with stress thallium-201 SPECT. J Nucl Med 1994; 35: 1279-1285.

    Google Scholar 

  9. Yamamichi Y, Kusukoa, H, Morishita K, et al. Metabolism of iodine-123 BMIPP in perfused rat hearts. J Nucl Med 1995; 36: 1043-1050.

    Google Scholar 

  10. Fujibayashi Y, Nohara R, Hosokawa R, et al. Metabolism and kinetics of iodine-123 BMIPP in canine myocardium. J Nucl Med 1996; 37: 757-761.

    Google Scholar 

  11. Hosokawa R, Nohara R, Fujibayashi Y, et al. Metabolic fate of iodine-123 BMIPP in canine myocardium after administration of etomoxir. J Nucl Med 1996: 37: 1836-1840.

    Google Scholar 

  12. Nohara R, Okuda K, Ogino M, et al. Evaluation of myocardial viability with iodine-123 in a canine model. J Nucl Med 1996; 37: 1403-1407.

    Google Scholar 

  13. Kobayashi H, Kusakabe K, Momose M, et al. Evaluation of myocardial perfusion and fatty acid uptake using a single injection of iodine-123 BMIPP in patients with acute coronary syndromes. J Nucl Med 1998; 39: 1117-1122.

    Google Scholar 

  14. Takeishi Y, Sukekawa H, Saito H, et al. Impaired fatty acid metabolism detected by I-123 BMIPP in patients with unstable angina pectoris: comparison with perfusion imaging by Tc-99m sestamibi. Ann Nucl Med 1995: 9: 125-130.

    Google Scholar 

  15. Tateno M, Tamaki N, Yukihiro M, et al. Assessment of fatty acid uptake in ischaemic heart disease without myocardial infarction. J Nucl Med 1996; 37: 1981-1985.

    Google Scholar 

  16. Saito S, Yasuda T, Gold HK, et al. Differentiation of regional perfusion and fatty acid uptake in zones of myocardial injury. Nucl Med Comm 1991; 12: 663-675.

    Google Scholar 

  17. Tamaki N, Kawamoto M, Yonekura Y, et al. Regional metabolic abnormality in relation to perfusion and wall motion in patients with myocardial infarction: assessment with emission tomography using an iodinated branched fatty acid analog. J Nucl Med 1992; 33: 659-667.

    Google Scholar 

  18. Nishimura T, Uehara T, Shimonagata T, Nagata S, Haze K. Clinical results with beta-methyl-p-iodophenyl-pentadecanoic acid, single-photon emission computed tomography in cardiac disease. J Nucl Cardiol 1994; 1: S65-S71.

    Google Scholar 

  19. De Geeter F, Franken PR, Knapp FF Jr, Bossuyt A. Relationship between blood flow and fatty acid metabolism in subacute myocardial infarction: a study by means of Tc-99m MIBI and I-123 beta-methyl iodophenyl pentadecanoic acid. Eur J Nucl Med 1994: 21; 283-291.

    Google Scholar 

  20. Tamaki N, Tadamura E, Kawamoto M, et al. Decreased uptake of iodinated branched fatty acid analog indicates metabolic alterations in ischaemic myocardium. J Nucl Med 1995; 36: 1974-1980.

    Google Scholar 

  21. Franken PR, De Geeter F, Dendale P, Demoor D, Block P, Bossuyt A. Abnormal free fatty acid uptake in subacute myocardial infarction after coronary thrombolysis: correlation with wall motion and inotropic reserve. J Nucl Med 1994; 35: 1758-1765.

    Google Scholar 

  22. Ito T, Tanouchi J, Kato J, et al. Recovery of impaired left ventricular function in patients with acute myocardial infarction is predicted by the discordance in defect size on BMIPP and thallium SPET images. Eur J Nucl Med 1996; 23: 917-923.

    Google Scholar 

  23. Fujiwara S, Takeishi Y, Atsumi H, et al. Prediction of functional recovery in acute myocardial infarction: comparison between sestamibi reverse redistribution and sestamibi/BMIPP mismatch. J Nucl Cardiol 1998; 5: 119-127.

    Google Scholar 

  24. Hashimoto A, Nakata T, Tsuchihashi K, Tana S, Fujimori K, Iimura O. Postischaemic functional recovery and BMIPP uptake after primary percutaneous transluminal coronary angioplasty in acute myocardial infarction. Am J Cardiol 1996; 77: 25-30.

    Google Scholar 

  25. Franken PR, Dendale P, De Geeter F, Demoor D, Bossuyt A, Block P. Prediction of functional outcome after myocardial infarction using BMIPP and sestamibi scintigraphy. J Nucl Med 1996; 37: 718-722.

    Google Scholar 

  26. Hambÿe AS, Vaerenberg M, Dobbeleir A, Van den Heuvel P, Franken PR. Abnormal BMIPP uptake in chronically dysfunctional myocardial segments: correlation with contractile response to low dose dobutamine. J Nucl Med 1998; 39: 1845-1850.

    Google Scholar 

  27. Hambÿe AS, Vaerenberg M, Vervaet A, Dobbeleir A, Franken PR. Combined sestamibi and free fatty acid metabolism scintigraphy for predicting revascularization functional recovery at rest and during dobutamine stimulation in chronic myocardial dysfunction. Am J Cardiol (submitted).

  28. Tamaki N, Tadamura E, Kudoh T, et al. Prognostic value of iodine-123 labelled BMIPP fatty acid analogue imaging in patients with myocardial infarction. Eur J Nucl Med 1996; 23: 272-279.

    Google Scholar 

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Authors and Affiliations

  1. University Hospital, Free University of Brussels (VUB), Brussels, Belgium

    Philippe R. Franken, Anne Sophie Hambÿe & Frank W. De Geeter

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  1. Philippe R. Franken
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  2. Anne Sophie Hambÿe
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  3. Frank W. De Geeter
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Franken, P.R., Hambÿe, A.S. & Geeter, F.W.D. BMIPP imaging to assess functional outcome in patients with acute and chronic left ventricular dysfunction. Int J Cardiovasc Imaging 15, 27–34 (1999). https://doi.org/10.1023/A:1006128116056

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  • DOI: https://doi.org/10.1023/A:1006128116056

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