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Novel Biological Process for L-DOPA Production from L-Tyrosine by P-Hydroxyphenylacetate 3-Hydroxylase

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Abstract

A novel biological method was developed for the production of L-3,4-dihydroxyphenylalanine (L-DOPA) from L-tyrosine by p-hydroxyphenylacetate 3-hydroxylase of Escherichia coli strain W (ATCC 11105). About 48 mM (or 1% w/v) L-DOPA was obtained by a fed batch operation in 50 h when a recombinant strain constitutively producing the enzyme was used.

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Author notes

  1. Jang-Young Lee

    Present address: Pacific R&D center, 314-1, Bora-ri, Kiheung-eup, Yongin-si, Kyonggi-do, 449-900, KOREA

Authors and Affiliations

  1. Environmental Microbiology Group, Battelle Pacific Northwest National Laboratory, PO Box 999, K4-06, Richland, WA, 99352, USA

    Jang-Young Lee & Luying Xun

  2. Department of Microbiology, Washington State University, Pullman, WA, 99164-4233, USA

    Luying Xun

Authors
  1. Jang-Young Lee
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  2. Luying Xun
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Lee, JY., Xun, L. Novel Biological Process for L-DOPA Production from L-Tyrosine by P-Hydroxyphenylacetate 3-Hydroxylase. Biotechnology Letters 20, 479–482 (1998). https://doi.org/10.1023/A:1005440229420

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  • DOI: https://doi.org/10.1023/A:1005440229420

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