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Platelet endothelial cell adhesion molecule in cell signaling and thrombosis

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Abstract

Platelet endothelial cell adhesion molecule (PECAM-1) is a member of the superfamily of immunoglobulins. This cell adhesion molecule has been implicated to mediate the adhesion and trans-endothelial migration of T lymphocytes/monocytes into the vascular wall, a critical step in the initiation of atherogenesis. Current thinking, however, posits that PECAM-1 by virtue of being a scaffolding molecule may well play a role in several signal transduction reactions. As a consequence, this cell adhesion molecule may be responsible for several biological and pathophysiological functions such as thrombosis, and inflammation. Evidence has also been put forward for a potential role of PECAM-1 in apoptosis and atherosclerosis. This article focuses on the structure of PECAM-1 and its role in intracellular signaling and implications in health and disease.

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    NanLing Gong & Subroto Chatterjee

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Gong, N., Chatterjee, S. Platelet endothelial cell adhesion molecule in cell signaling and thrombosis. Mol Cell Biochem 253, 151–158 (2003). https://doi.org/10.1023/A:1026016628386

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