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HGF/SF in Mammary Epithelial Growth and Morphogenesis: In Vitro and In Vivo Models

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Abstract

HGF/SF is a multifunctional cytokine whichthrough binding to its cellular receptor, c-MET, canelicit mitogenic, morphogenic and motogenic responses intarget cells. Expression of HGF/SF and c-MET has been shown to be critical in earlyembryogenesis affecting development of many organs andtissues. The effects of HGF/SF4 on established human andmouse mammary cell lines have previously been reported. This review describes the source and targetsfor HGF/SF in both human and mouse mammary tissue anddiscusses the effects of HGF/SF on primary mouse andhuman mammary epithelial cells in vitro, detailing the individual response of the two epithelialsub-population of cells which comprise this organ.Additionally, the effects of HGF/SF overexpression onmouse mammary gland development in vivo, aresummarized.

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Authors
  1. Tahereh Kamalati
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  2. Birunthi Niranjan
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  3. Jeffrey Yant
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  4. Lakjaya Buluwela
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Kamalati, T., Niranjan, B., Yant, J. et al. HGF/SF in Mammary Epithelial Growth and Morphogenesis: In Vitro and In Vivo Models. J Mammary Gland Biol Neoplasia 4, 69–77 (1999). https://doi.org/10.1023/A:1018756620265

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