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Effect of small scale culture vessel type on hyphal fragment size and erythromycin production in Saccharopolyspora erythraea

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Abstract

Erythromycin production dynamics in stirred, baffled shaken and non-baffled shaken flasks was strongly correlated with the different distributions of hyphal particle diameters observed. Production only took place when hyphal fragments with diameters greater than 88 μm were observed. Results are consistent with significant hyphal breakage rates, even in non-baffled shaken flasks.

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Authors and Affiliations

  1. Microbial Products Laboratory, School of Biological Sciences, University of Surrey, Guildford Surrey, UK

    M.E. Bushell, G.L. Dunstan & G.C. Wilson

Authors
  1. M.E. Bushell
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  2. G.L. Dunstan
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  3. G.C. Wilson
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Bushell, M., Dunstan, G. & Wilson, G. Effect of small scale culture vessel type on hyphal fragment size and erythromycin production in Saccharopolyspora erythraea. Biotechnology Letters 19, 849–852 (1997). https://doi.org/10.1023/A:1018325301500

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  • DOI: https://doi.org/10.1023/A:1018325301500

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