Skip to main content
SpringerLink
Log in

Antipyretic Effect of Neuropeptide Galanin in Endotoxin-Induced Fever

  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Neuropeptide galanin produces a antipyretic effect in experimental pyrogenic reaction induced by intraperitoneal injection of lipopolysaccharide. Central intracerebroventricular injection of 100 ng galanin significantly attenuated, but did not completely abolish fever. Central galanin injection potentiated endotoxin-induced activation of the noradrenergic system and blocked activation of the serotoninergic system of the anterior hypothalamus.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

REFERENCES

  1. O. E. Zubareva, I. N. Abdurasulova, I. N. Krasnova, and V. M. Klimenko, Neirokhimiya, 14, No. 4, 362–368 (1997).

    Google Scholar 

  2. V. M. Klimenko, V. I. Lyudyno, U. Langel., et al., Byull. Eksp. Biol. Med., 125, No. 4, 430–433 (1998).

    Google Scholar 

  3. A. T. Mar'yanovich, Fiziol. Cheloveka, 22, No. 2, 35–42 (1996).

    Google Scholar 

  4. V. I. Morozov, V. S. Chaikovskii, S. A. Priyatkin, et al., Fiziol. Zh. SSSR, No. 8, 1049–1072 (1988).

  5. J. Bligh, Neurosci., 4, No. 9, 1213–1236 (1979).

    Google Scholar 

  6. A. J. Dunn, J. Pharmacol. Exp. Ther., 261, 964–969 (1992).

    Google Scholar 

  7. M. V. Gonzalez Nicolini, A. A. Orezzoli, and M. J. Villar, Cen. Comp. Endocrinol., 110, No. 2, 175–181 (1998).

    Google Scholar 

  8. S. C. Hooi, D. M. Maiter, J. B. Martin, and J. I. Koenig, Endocrinology, 127, 2281–2289 (1990).

    Google Scholar 

  9. K. Kask, U. Langel, and T. Bartfai, Cell. Mol. Neurobiol., 15, No. 6, 653–673 (1995).

    Google Scholar 

  10. M. T. Lin, A. Chandra, Y. F. Chern, and B. L. Tsay, Can. J. Physiol. Pharmacol., 58, 896–902 (1980).

    Google Scholar 

  11. T. Melander, T. Hokfelt, A. Rokaeus, et al., J. Neurosci., 6, 3640–3654 (1986).

    Google Scholar 

  12. J. A. Menendez, D. M. Atrens, and S. F. Leibowitz, Peptides, 13, 323–327 (1992).

    Google Scholar 

  13. I. Merchenthaler, F. J. Lopez, A. Negro-Vilar, Progr. Neurobiol., 40, 711–769 (1993).

    Google Scholar 

  14. M. Niimi, J. Takahara, and K. Kawanishi, Neurosci. Res., 14, 295–299 (1992).

    Google Scholar 

  15. E. Palazzi, G. Fisone, T. Hokfelt, et al., Eur. J. Pharmacol., 148, 479–480 (1988).

    Google Scholar 

  16. N. J. Rothwell and A. L. Cooper, Neuroimmunology of Fever, Oxford, N.Y., 257–266 (1992).

Download references

Author information

Authors and Affiliations

  1. Institute of Experimental Medicine, Russian Academy of Medical Science, Moscow

    V. I. Lyudyno, I. N. Krasnova, M. P. Smirnova & V. M. Klimenko

  2. Institute of Extrapure Biopreparations, St.-Petersburg

    V. I. Lyudyno, I. N. Krasnova, M. P. Smirnova & V. M. Klimenko

Authors
  1. V. I. Lyudyno
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. I. N. Krasnova
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. M. P. Smirnova
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. V. M. Klimenko
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lyudyno, V.I., Krasnova, I.N., Smirnova, M.P. et al. Antipyretic Effect of Neuropeptide Galanin in Endotoxin-Induced Fever. Bulletin of Experimental Biology and Medicine 131, 60–63 (2001). https://doi.org/10.1023/A:1017538814753

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/A:1017538814753

Search

Navigation