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Drug/Polymer Matrix Swelling and Dissolution

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Abstract

The swelling and dissolution behavior of pharmaceutical systems containing a drug and a polymer can be analyzed by a mathematical model which predicts the drug released and the gel layer thickness as a function of time. It is possible to approximate the values of several of the physicochemical parameters of this model in order to obtain an order-of-magnitude analysis of the tablet dissolution process. Selected experimental results of tablet dissolution and drug release are analyzed and conclusions are made about the importance of the drug and polymer content and solubility in the release behavior.

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Authors and Affiliations

  1. School of Chemical Engineering, Purdue University, West Lafayette, Indiana, 47907

    Ronald S. Harland & Nikolaos A. Peppas

  2. Department of Pharmaceutical Chemistry, University of Pavia, 27100, Pavia, Italy

    Andrea Gazzaniga & M. Edvige Sangalli

  3. Institute of Pharmaceutical Technology, University of Parma, 43100, Parma, Italy

    Paolo Colombo

Authors
  1. Ronald S. Harland
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  2. Andrea Gazzaniga
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  3. M. Edvige Sangalli
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  4. Paolo Colombo
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  5. Nikolaos A. Peppas
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Harland, R.S., Gazzaniga, A., Sangalli, M.E. et al. Drug/Polymer Matrix Swelling and Dissolution. Pharm Res 5, 488–494 (1988). https://doi.org/10.1023/A:1015913207052

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  • DOI: https://doi.org/10.1023/A:1015913207052

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