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Vitamin D receptor genotype and breast cancer in Latinas (United States)

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Abstract

Objective: Polymorphism in the vitamin D receptor (VDR) gene has been associated with variation in bone mineral density and with prostate cancer risk. The purpose of this study was to determine whether polymorphism in the VDR gene may also influence breast cancer risk.

Methods: Polymorphisms in the 5′ and 3′ ends of the VDR gene were genotyped for 143 Latina women with breast cancer and 300 cohort controls.

Results: Both the BsmI and poly-A polymorphisms in the 3′ end of the VDR gene were associated with breast cancer risk, with a trend for increasing risk with increasing number of BsmI B alleles or short (S) poly-A alleles. Compared to subjects having two long poly-A alleles (genotype LL), odds ratios (and 95% confidence intervals) were 1.5 (1.0–2.3) and 3.2 (1.5–6.9) for subjects having genotypes SL and SS, respectively. Compared to BsmI genotype bb, odds ratios (and 95% confidence intervals) were 1.6 (1.1–2.5) and 2.2 (1.0–4.7) for genotypes Bb and BB respectively. The start codon polymorphism, FokI, was not associated with breast cancer risk.

Conclusion: These results suggest that polymorphic variation in or near the 3′ end of the VDR gene influences breast cancer risk in Latina women.

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Authors and Affiliations

  1. Department of Preventive Medicine, University of Southern California/Norris Comprehensive Cancer Center, 1441 Eastlake Ave, MS 44, Room 6419, Los Angeles, CA, 90033

    Sue Ann Ingles, Diana G. Garcia, Wei Wang, Alexandra Nieters, Brian E. Henderson & Robert W. Haile

  2. Cancer Research Center, University of Hawaii, Honolulu, HI

    Laurence N. Kolonel

  3. Department of Urology, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, CA

    Gerhard A. Coetzee

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  1. Sue Ann Ingles
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  2. Diana G. Garcia
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  3. Wei Wang
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  7. Robert W. Haile
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  8. Gerhard A. Coetzee
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Ingles, S.A., Garcia, D.G., Wang, W. et al. Vitamin D receptor genotype and breast cancer in Latinas (United States). Cancer Causes Control 11, 25–30 (2000). https://doi.org/10.1023/A:1008979417618

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  • DOI: https://doi.org/10.1023/A:1008979417618

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