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Effect of Low-Dose Aspirin on the Markers of Oxidative Stress

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Abstract

Summary. The present study estimates effects of low-dose enteric coated aspirin (ECA) on oxidative stress (OS) markers in a group of middle-aged men (mean age 51.2 ± 6.9 years) free of pre-existing ischemic heart disease.

Methods. Serum products of lipid peroxidation, and measures of antioxidative status were detected in 25 healthy men in baseline and after two-week treatment period.

Results. In respect to serum products of lipid peroxidation and markers of antioxidant status, no statistically significant differences between the pre- and after-treatment data were observed for any measures, with the exception of values of serum antioxidative capacity (39.0 ± 2.5 and 42 ± 4.6, respectively).

Conclusions. Administration of ECA does not initiate the OS in blood and improves the general antioxidative potency of blood. This may imply towards certain antiatherogenic influence of low-dose ECA, exhibited even with a short-term treatment period. Regarding OS markers, a variety of individual responses observed in the selected subgroups should be investigated and possibly taken into account while treatment with ECA is initiated for primary prevention of cerebrovascular events.

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Authors and Affiliations

  1. Department of Cardiology, Faculty of Medicine, University of Tartu, Tartu, EE 51014, Estonia

    Tiina Ristimäe & Rein Teesalu

  2. Department of Biochemistry, Faculty of Medicine, University of Tartu, Tartu, Estonia

    Mihkel Zilmer, Kersti Zilmer, Czeslawa Kairane & Tiiu Kullisaar

Authors
  1. Tiina Ristimäe
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  2. Mihkel Zilmer
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  3. Kersti Zilmer
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  4. Czeslawa Kairane
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  5. Tiiu Kullisaar
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Ristimäe, T., Zilmer, M., Zilmer, K. et al. Effect of Low-Dose Aspirin on the Markers of Oxidative Stress. Cardiovasc Drugs Ther 13, 485–490 (1999). https://doi.org/10.1023/A:1007867402152

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