Abstract
The PREMAP Study investigated the prevalence and risk factors of dementia and Alzheimer's Disease (AD) in a random sample of 1062 residents 70 year old or more, living in south-eastern France (private homes and institutions). All persons living in institutions for the elderly (n = 258) and community dwellers (n = 804) scoring less than 24 points on the MMSE (18.4%) were invited to undergo a medical evaluation at home by a qualified neurologist using the CERAD battery. We found 177 cases of dementia (9.2%), including 82 cases of AD (5.5%). Prevalence of AD increased significantly with age and was higher among women (OR: 4.24) and persons with no formal educational level (OR: 2.47). While a MMS score less than 24 was more frequent among persons with a foreign native language (OR: 3.05), the OR of AD was not significantly associated with native language. The proportion of AD among persons suffering from senile dementia was 45% among elderly living in institutions and 69% among those living in the community. Prevalence rates in south-eastern France are similar to the average rates for Europe. This study underlines the need to investigate the relationships between native language, MMSE and AD on the one hand, and the link between a low MMSE score and institutionalisation of patients suffering from AD on the other.
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Rocca WA, Hofman A, Amaducci L. Prevalence of Alzheimer's disease and other dementing disorders in Europe: A collaborative reanalysis of 1980–1990 findings. Rotterdam, The Netherlands: EURODEM, 1990: 1–31.
Dartigues JF, Baberger-Gateau P, Salamon R, et al. The PAQUID Research program on the epidemiology of dementia: Methods and first results. Rev Neurol 1991; 147: 225–230.
Hofman A, Rocca WA, Brayne C, et al. The prevalence of dementia in Europe: A collaborative study of 1980–1990 findings. Int J Epidemiol 1991; 20: 736–748.
Degrand-Guillaud A, Obadia Y, Guelain J. Méthodologie d'enquête sur la prévalence de la maladie d'Alzheimer dans les Bouches du Rhône. Rev Epidemiol Santé Publique 1991; 39: 413–416.
Alperovitch A. L'épidémiologie peut-elle contribuer à la prévention des démences? Actes du 2è colloque CNAMTS-INSERM 1988; 187: 227–228.
Folstein M, Folstein F, Mc Hugh PR. Mini mental state: A practical method for grading the cognitive state of patients for the clinicien. J Psychiatric Res 1975; 12: 189–198.
Pfeffer RI, Afifi AA. Prevalence of Alzheimer's disease in a retirement community. Am J Epidemiol 1987; 125: 420–436.
American Psychiatric Association. Manuel diagnostique et statistique des troubles mentaux: DSM-III-R. Paris: Masson, 1987.
Mc Khann G, Drachman D, et al. Report of the NINCDS-ADRDA work group under the auspices of department of health and human services task force on Alzheimer's disease. Neurology 1984; 34: 939–944.
Morris JC, Heyman A, Mohs RC, et al. The consortium to establish a registry for Alzheimer's disease (CERAD). Neurology 1989; 39: 1159–1164.
Bouyer J. La régression logistique en épidémiologie, Partie II. Rev Epidemiol Santé Publique 1991; 39(2): 183–196, ISSN: 0398-76.
Rocca WA, Bonaiuto S, Lippi A, et al. Prevalence of clinically diagnosed Alzheimer's disease and other dementing disorders: A door to door survey in Appignano, Macerata province, Italy. Neurology 1990; 40: 626–631.
Breteler MMB, Vandenouweland FA, Grobbee DE, Hofman A. A community based study of dementia: The Rotterdam Elderly Study. Neuroepidemiol 1992; 11(suppl 1): 23–28.
Lobo A, Saz P, Dia JL, et al. The epidemiological study of dementia in Zaragoza, Spain. In: Stefaniss CN, Soldators CR, Rabavilas A (eds), Psychiatry: A world perspective. Proceedings 8th World Congress of Psychiatry, Athens, 1989.
Sulkava R, Wilkström J, Aromaa A, et al. Prevalence of severe dementia in Finland. Neurology 1985; 35: 1025–1029.
OConnor DW, Pollit PA, Hyde JB, et al. The prevalence of dementia as measured by the Cambridge mental disorders of the elderly examination. Acta Psychiatric Scand 1989; 79: 190–198.
Dealberto MJ, Gagnon M, Baberger-Gateau P, Dartigues JF, Alperovitch A. Influence du niveau d'études sur un test de dépistage de la démence, le mini mental state examination. Rev Epidemiol Santé Publique 1992; 40: 93–101.
Gagnon M, Letenneur L, Dartigues JF. The validity of the mini mental state examination as a screening instrument for cognitive impairment and dementia in French elderly community residents. Neuroepidemiology 1990; 9: 143–150.
Bachman DL, Wolf PA, Linn R, Knoefel JE, et al. Prevalence of dementia and probable senile dementia of the Alzheimer type in the Framingham Study. Neurology 1992; 42: 115–119.
Fuhrer R, Antonucci T, Gagnon M, Dartigues JF, Baberger-Gateau P, Alperovitch A. Depressive symptomatology and cognitive functioning: An epidemiological survey in an elderly community sample in France. Psychol Med 1992; 22: 159–172.
Evans D, Funkenstein H, Albert M, et al. Prevalence of Alzheimer's disease in a community population of older persons. JAMA 1989; 262: 2551–2556.
Jorm AF, Korten AE, Henderson AS. The quantitative integration of literature. Acta Psychiatric Scand 1987; 76: 465–479.
Mortimer JA. Epidemiology of dementia: Cross-cultural comparisons. In: Richard Wurtman, et al. (eds), Advances in neurology, Vol 51: Alzheimer's disease. New York: Raven Press, 1990.
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Obadia, Y., Rotily, M., Degrand-Guillaud, A. et al. The PREMAP Study: Prevalence and risk factors of dementia and clinically diagnosed Alzheimer's disease in Provence, France. Eur J Epidemiol 13, 247–253 (1997). https://doi.org/10.1023/A:1007300305507
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DOI: https://doi.org/10.1023/A:1007300305507