Skip to main content
SpringerLink
Log in

Computational dosimetry and treatment planning for Boron Neutron Capture Therapy

  • Published:
Journal of Neuro-Oncology Aims and scope Submit manuscript

Abstract

The technology for computational dosimetry and treatment planning for Boron Neutron Capture Therapy (BNCT) has advanced significantly over the past few years. Because of the more complex nature of the problem, the computational methods that work well for treatment planning in photon radiotherapy are not applicable to BNCT. The necessary methods have, however, been developed and have been successfully employed both for research applications as well as human trials, although further improvements in speed are needed for routine clinical applications. Computational geometry for BNCT applications can be constructed directly from tomographic medical imagery and computed radiation dose distributions can be readily displayed in formats that are familiar to the radiotherapy community.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Stone RS: Neutron therapy and specific ionization. Am J Roentgenol 59: 771–785, 1940

    Google Scholar 

  2. Laramore GE, Griffin TE: Fast Neutron Radiotherapy–Where Have We Been and Where Are We Going? Int J Rad Onc Bio Phys 32: 879–882, 1995

    Google Scholar 

  3. Locher GL: Biological effects and therapeutic possibilities of neutrons. Am J Roentgenol 36: 1–13, 1936

    Google Scholar 

  4. Sweet WH: The use of nuclear disintegrations in the diagnosis and treatment of brain tumors. N Engl J Med 245: 875–878, 1951

    Google Scholar 

  5. Farr LE, Sweet WH, Robertson JS, Foster CG, Locksley HB, Sutherland DL, Mendelsohn ML, Stickley EE: Neutron capture therapy with boron in the treatment of glioblastoma multiforme. Am J Roentgenol 71: 279–291, 1954

    Google Scholar 

  6. Godwin JT, Farr LE, Sweet WH, Robertson JS: Pathological study of eight patients with glioblastoma multiforme treated by neutron capture therapy using boron-10. Cancer (Phila.) 8: 601–615, 1955

    Google Scholar 

  7. Javid M, Brownell GL, Sweet WH: The possible use of neutron-capture isotopes such as boron-10 in the treatment of neoplasmms. II. Computation of the Radiation Energy and estimates of effects in normal and neoplastic brain. J Clin Invest 31: 603–610, 1952

    Google Scholar 

  8. Soloway AH, Hatanaka H, Davis MA: Penetration of brain and tumor. VII. Tumor binding sulfhydryl boron compounds. J Medicinal Chem 10: 714–717, 1967

    Google Scholar 

  9. Hatanaka H, Kamano S, Amano K, Hojo S, Sano K, Egawa S, Yasukochi H: Clinical experience of boron neutron capture therapy for gliomas–A comparison with conventional chemo-immuno-radiotherapy. In: Hatanaka H (ed) Boron Neutron Capture Therapy for Tumors, Nishimura, Niigata, Japan, 1986, pp 349–378

    Google Scholar 

  10. Hatanaka H, Urano Y: Eighteen autopsy cases of malignant brain tumors treated by boron neutron capture therapy between 1968 and 1985. In: Hatanaka H (ed) Boron Neutron Capture Therapy for Tumors, Nishimura, Niigata Japan, 1986, pp 381–416

    Google Scholar 

  11. Hatanaka H: Boron neutron capture therapy for tumors. In: Karim ABM, Laws ER Jr (eds) Glioma. Springer Verlag, Berlin, 1991, pp 233–249

    Google Scholar 

  12. Coderre JA, Bergland R, Capala J, Chadha M, Chanana AJ, Elowitz E, Joel DD, Liu HB, Slatkin D: Boron Neutron Capture Therapy for Glioblastoma Multiforme using p-Boronophenylalanine and epithermal neutrons–Trial design and early clinical results. J Neurooncol 33: 141–152, 1997

    Google Scholar 

  13. Madoc-Jones H, Zamenhof R, Solares G, Harling O: Clinical trial begins at MIT/NEMC, In: Mishima Y (ed) Proceedings of the 6th International Symposium on Neutron Capture Therapy, Kobe, Japan, November, 1994, Plenum Press, New York

    Google Scholar 

  14. Laramore GE, Wootton, P, Livesey JC, Wilbur DS, Risler R, Phillips M, Jacky J, Bucholtz TA, Griffin TW, Brossard S: Boron neutron Capture therapy–A mechanism for achieving a concomitant tumor boost in fast neutron radiotherapy. Int J Rad Onc Bio Phys 28: 1135–1142, 1994

    Google Scholar 

  15. Alpen EL, Frankel KA: Biological effectiveness of recoil protons from neutrons of energy 5 keV to 5 MeV. In: Soloway AH, Barth RF, Carpenter DE (eds) Advances in Neutron Capture Therapy, Plenum Press, New York 1993, pp 201–206

    Google Scholar 

  16. Gabel D, Foster S, Fairchild, R: The Monte Carlo simulation of the biological effect of the 10B(n,alpha)7Li reaction in cells and tissue and its implication for boron neutron capture therapy. Rad Res 111: 14–25, 1987

    Google Scholar 

  17. Gavin PR, Huiskamp R, Wheeler FJ, Griebenow ML: Computer modeling the boron compound factor in normal brain tisssue and computer modeling the boron compound factor in brain tumors, In: Barth R, Soloway A (eds) Advances in Neutron Capture Therapy, Plenum Press, New York, NY, 1993, pp 591–602

    Google Scholar 

  18. Rydin RA, Deutsch OL, Murray BW: The effect of geometry on capillary wall dose for boron neutron capture therapy. Phys Med Bio 21: 134, 1975

    Google Scholar 

  19. Solares GR, Zamenhof RG: A novel approach to the microdosimetry of neutron capture therapy–Part 1, High resolution quantitative autoradiography of neutron capture therapy. Rad Res 144: 50–58, 1995

    Google Scholar 

  20. Takeuchi A, Nagata T, Ohashi F, Sasaki N, Ushio Y, and Hatanaka H: Tolerance of canine brain to boron neutron capture therapy. Japanese Journal of Veterinary Science 47: 859, 1985

    Google Scholar 

  21. Wheeler FJ: Microdosimetric calculations of boron-drug compound factors for boron neutron capture therapy. Trans American Nuclear Soc 65: 147, 1992

    Google Scholar 

  22. Zamenhof RG: Microdosimetry and its application to clinical studies. J Neurooncol 33: 81–91, 1997

    Google Scholar 

  23. Kinsey R: Data Formats and Procedures for the Evaluated Nuclear Data File ENDF. Report Number BNLNCS-50496, Brookhaven National Laboratory, NY, 1979

    Google Scholar 

  24. Briesmeister JF (ed): MCNP–A General Monte Carlo Code for Neutron and Photon Transport, Version 3A. Report Number LA-7396-M, Revision 2, Los Alamos, National Laboratory, Los Alamos, NM, USA (1986)

    Google Scholar 

  25. Zamenhof R, Brenner J, Yanch J, Wazer D, Madoc-Jones H. Saris S, Harling O: Treatment planning for neutron capture therapy of glioblastoma multiforme using epithermal neutron beam from the MITR-II research reactor and Monte Carlo simulation.In: Allen BJ, Moore DE, Harrington BV (eds) Progress In Neutron Capture Therapy for Cancer, Plenum Press, New York, NY, 1992, pp 173–178

    Google Scholar 

  26. Nigg DW: Methods for radiation dose distribution analysis and treatment planning in boron neutron capture therapy. Int J Rad Onc Bio Phys 28: 1121–1134, 1994

    Google Scholar 

  27. Wheeler FJ, Nigg DW: Three-dimensional radiation dose distribution analysis for boron neutron capture therapy. Nucl Sci Eng 110: 16–31, 1992

    Google Scholar 

  28. Wessol DE, Wheeler FJ: Methods for creating and using free-form geometries in Monte Carlo particle transport. Nucl Sci Eng 113: 314–323, 1993

    Google Scholar 

  29. Nigg DW, Randolph PD, Wheeler FJ: Demonstration of three dimensional deterministic radiation transport theory dose distribution analysis for boron neutron capture therapy. Med Phys 18: 43–53, 1991

    Google Scholar 

  30. Moran JM, Nigg DW, Wheeler FJ, Bauer WF: Macroscopic geometric heterogeneity effects in radiation dose distribution analysis for boron neutron capture therapy. Med Phys 19: 723–732, 1993

    Google Scholar 

  31. Niemkiewicz J, Blue TE: Removal-diffusion theory for calculation of neutron distributions in BNCT. In: Barth R, Soloway A (eds) Advances in Neutron Capture Therapy, Plenum Press, New York, NY, 1993, pp 177–180

    Google Scholar 

  32. Liu HB, Brugger RM, Greenberg DD, Rorer DC, Hu JP, Hauptman HM: Enhancement of the epithermal-neitron beam used for boron neutron capture therapy. Int J Rad Onc Bio Phys 28: 1149–1156, 1994

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Idaho National Engineering Laboratory, Box 1625, Idaho Falls, ID, 83415, USA

    David W. Nigg, Floyd J. Wheeler & Daniel E. Wessol

  2. Brookhaven National Laboratory, Upton, NY, 11973, USA

    Jacek Capala

  3. Beth Israel Medical Center, New York, NY, 10003, USA

    Manjeet Chadha

Authors
  1. David W. Nigg
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Floyd J. Wheeler
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Daniel E. Wessol
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Jacek Capala
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Manjeet Chadha
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Nigg, D.W., Wheeler, F.J., Wessol, D.E. et al. Computational dosimetry and treatment planning for Boron Neutron Capture Therapy. J Neurooncol 33, 93–103 (1997). https://doi.org/10.1023/A:1005777416716

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/A:1005777416716

Search

Navigation