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Relationship between Locomotor Activity and Monoamines Following Single and Double Transient Forebrain Ischemia in Gerbils

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Abstract

The relationship between locomotor activity and monoamine levels in gerbils after single and/or double forebrain ischemic insult was studied. Locomotor hyperactivity was observed after the first ischemic episode, but the gerbils failed to show hyperactivity after the second ischemic episode induced one week later. The monoamine levels were determined in order to clarify the biochemical basis of post-ischemic locomotor hyperactivity. Norepinephrine increased in response to first ischemic episode but remained at normal levels after the second episode of ischemia. Metabolites of dopamine and serotonin increased after both the first and second ischemic insults, which indicates that these monoamines do not play significant roles in post-ischemic locomotor activity. Therefore, increases in norepinephrine after first ischemic insult may play a role in increasing locomotor activity during the period following such an episode.

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REFERENCES

  1. Chandler, M. J., DeLeo, J., and Carney, J. M. 1985. An anesthetized gerbil model of cerebral ischemia-induced behavioral changes. J. Pharmacol. Meth. 14:137–146.

    Google Scholar 

  2. Gerhardt, S. C. and Boast, C. A. 1988. Motor activity changes following cerebral ischemia in gerbils are correlated with the degree of neuronal degeneration in hippocampus. Behav. Neurosci. 102:301–303.

    Google Scholar 

  3. Mileson, B. E. and Schwartz, R. D. 1991. The use of locomotor activity as a behavioral screen for neuronal damage following transient forebrain ischemia in gerbils. Neurosci. Lett. 128:71–76.

    Google Scholar 

  4. Cvejić, V., Mićić, D. V., Djuričić, B. M., Mršulja, B. J., and Mršulja, B. B. 1980. Monoamines and related enzymes in cerebral cortex and basal ganglia following transient ischemia in gerbils. Acta Neuropath. (Berl) 51:71–77.

    Google Scholar 

  5. Gaudet, R., Welch, K. M. A., Chabi, E., and Wang, T. 1978. Effect of transient ischemia on monoamine levels in the cerebral cortex of gerbils. J. Neurochem. 30:751–757.

    Google Scholar 

  6. Izumi, J., Inagaki, M., Kiuchi, Y., Matsumoto, M., Yamazaki, Y., Morioka, D., Usami, S., and Oguchi, K. 1993. Sustained increase in adrenergic activity in gerbil striatum following transient ischemia. Japan. J. Pharmacol. 63:143–149.

    Google Scholar 

  7. Matsumoto, M., Kimura, K., Fujisawa, A., Matsuyama, T., Fukunaga, R., Yoneda, S., Wada, H., and Abe, H. 1984. Differential effect of cerebral ischemia on monoamine content of discrete brain regions of the Mongolian gerbil (Meriones unguiculatus). J. Neurochem. 42:647–651.

    Google Scholar 

  8. Phebus, L. A. and Clemens, J. A. 1989. Effects of transient, global, cerebral ischemia on striatal extracellular dopamine, serotonin and their metabolites. Life Sci. 44:1335–1342.

    Google Scholar 

  9. Uchiyama-Tsuyuki, Y., Hiroaki, A., Karasawa, Y., and Aihara, H. 1989. Changes in monoamine contents in the brains of mongolian gerbils following a 5-min occlusion of the bilateral carotid arteries. Japan. J. Pharmacol. 50:357–361.

    Google Scholar 

  10. Arnt, J. 1987. Behavioral studies of dopamine receptors: evidence for regional selectivity and receptor multiplicity. Pages 199–213, in Creese, I. and Fraser, C. M. (Eds.), Receptor Biochemistry and Methodology, Alan R. Liss, New York.

    Google Scholar 

  11. Shreve, P. E. and Uretsky, N. J. 1989. AMPA, Kainic acid, and N-methyl-D-aspartic acid stimulate locomotor activity after injection into the substantia innominata/lateral preoptic area. Pharmacol. Biochem. Behav. 34:101–106.

    Google Scholar 

  12. Benveniste, H., Drejer, J., Schousboe, A., and Diemer, N. H. 1984. Elevation of the extracellular concentrations of glutamate and aspartate in rat hippocampus during transient cerebral ischemia monitored by intracerebral microdialysis. J. Neurochem. 43:1369–1374.

    Google Scholar 

  13. Globus, M. Y. T., Busto, R., Dietrich, W. D., Martinez, E., Valdes, I., and Ginsberg, M. D. 1989. Direct evidence for acute and massive norepinephrine release in the hippocampus during transient ischemia. J. Cereb. Blood Flow Metab. 9: 892–896.

    Google Scholar 

  14. Hillerd, L., Hallstrom, A., Segersvard, S., Persson, L., and Ungerstedt, U. 1989. Dynamics of extracellular metabolites in the striatum after middle cerebral artery occlusion in the rat monitored by intracerebral microdialysis. J. Cereb. Blood Flow Metab. 9:607–616.

    Google Scholar 

  15. Hall, C. S. 1934. Emotional behaviour in the rat. I. Defecation and urination as a measures of individual differences in emotionality. J. Comp. Psychol. 1:385–403.

    Google Scholar 

  16. Glowinski, J. and Iversen, L. 1966. Regional studies of catecholamines in the rat brain I. J. Neurochem. 13:655–669.

    Google Scholar 

  17. Tanaka, K., Ogawa, N., Asanuma, M., Hirata, H., Kondo, Y., Nakayama, N., and Mori, A. 1993. Effects of the acetylcholinesterase inhibitor ENA-713 on ischemia-induced changes in acetylcholine and aromatic amine levels in the gerbil brain. Arch. Int. Pharmacodyn. 323:85–95.

    Google Scholar 

  18. Araki, H., Nojiri, M., Kawashima, K., Kimura, M., and Aihara, H. 1986. Behavioral, electroencephalographic and histopathological studies on mongolian gerbils with occluded common carotid arteries. Physiol. Behav. 38:89–94.

    Google Scholar 

  19. Araki, H., Nojiri, M., Kimura, M., and Aihara, H. 1986. Effect of minaprine on “delayed neuronal death” in mongolian gerbils with occluded common carotid arteries. J. Pharmacol. Exp. Ther. 242:686–691.

    Google Scholar 

  20. Crain, B. J., Westerkam, W. D., Harrison, A. H., and Nadler, J. V. 1988. Selective neuronal death after transient forebrain ischemia in the Mongolian gerbil: a silver impregnation study. Neuroscience 27:387–402.

    Google Scholar 

  21. Lin, C. S., Polsky, K., Nadler, J. V., and Crain, B. J. 1990. Selective neocortical and thalamic cell death in the gerbil after transient ischemia. Neuroscience 35:289–299.

    Google Scholar 

  22. Kuroiwa, T., Bonnekoh, P., and Hossmann, K. A. 1991. Locomotor hyperactivity and hippocampal CA1 injury after transient forebrain ischemia of gerbils. Neurosci. Lett. 122: 141–144.

    Google Scholar 

  23. Piera, M. J., Beaughard, M., Michelin, M. T., and Massingham, R. 1995. Effects of the 5-hydroxytryptamine1A receptor agonists, 8-OH-DPAT, buspirone and flesinoxan, upon brain damage induced by transient global cerebral ischaemia in gerbils. Arch. Int. Pharmacodyn. Ther. 329:347–359.

    Google Scholar 

  24. Maginn, M., Kelly, J. P., and Leonard, B. E. 1997. Protective effects of vanoxeamine (GBR 12909) against ischaemia-induced hyperactivity and neurodegeneration in the gerbil model of cerebral ischaemia. Pharmacol. Biochem. Behav. 56:727–735.

    Google Scholar 

  25. Araki, H., Hino, N., Karasawa, Y., Kawasaki, H., and Gomita, Y. 1999. Eeffect of dopamine blockers on cerebral ischemiainduced hyperactivity in gerbils. Physiol. Behav. 66:263–268.

    Google Scholar 

  26. Brown, R. M., Kehr, W., and Carlsson, A. 1975. Functional and biochemical aspects of catecholamine metabolism in the brain under hypoxia. Brain Res. 85:491–509.

    Google Scholar 

  27. Mršulja, B. B., Mršulja, B. J., Cvejić, V., Djuričić, B. M., and Rogač, L. 1978. Alterations of putative neurotransmitters and enzymes during ischemia in gerbil cerebral cortex. J. Neural. Transm. (Suppl) 14:23–30.

    Google Scholar 

  28. Cooper, J. R., Bloom, F. E., and Roth, R. H. (Eds.), 1996. The Biochemical Basis of Neuropharmacology, page 343, Oxford University Press, New York.

    Google Scholar 

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Authors and Affiliations

  1. Department of Neuroscience, Institute of Molecular and Cellular Medicine, Okayama University Medical School, Okayama, 700-8558, Japan

    M. Emdadul Haque, Ken-ichi Tanaka & Norio Ogawa

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  1. M. Emdadul Haque
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  2. Ken-ichi Tanaka
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  3. Norio Ogawa
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Haque, M.E., Tanaka, Ki. & Ogawa, N. Relationship between Locomotor Activity and Monoamines Following Single and Double Transient Forebrain Ischemia in Gerbils. Neurochem Res 26, 401–406 (2001). https://doi.org/10.1023/A:1010955232404

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