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Extracellular Matrix and Growth Factors During Heart Growth

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Abstract

The effects of growth factors on tissue remodeling and cell differentiation depend on the nature of the extracellular matrix, the type and organization of integrins, the activation of metalloproteinases and the presence of secreted proteins associated to the matrix. These interactions are actually poorly known in the cardiovascular system. We describe here: 1) the main components of extracellular matrix within the cardiovascular system; 2) the role of integrins in the transmission of growth signals; 3) the shift in the expression of the components of the extracellular matrix (fibronectin and collagens) and the stimulation of the synthesis of metalloproteinases during normal and hypertrophic growth of the myocardium; 4) the effects of growth factors, such as Angiotensin II, Fibroblast Growth Factors (FGF), Transforming Growth Factor-β (TGF-β), on the synthesis of proteins of the extracellular matrix in the heart.

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  1. Hôpital Lariboisière, INSERM U 127, France

    Stefano Corda, Jane-Lise Samuel & Lydie Rappaport

  2. Service de Biophysique, Hôpital Lariboisière-Université Paris 7, 75010, PARIS, France

    Stefano Corda

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Corda, S., Samuel, JL. & Rappaport, L. Extracellular Matrix and Growth Factors During Heart Growth. Heart Fail Rev 5, 119–130 (2000). https://doi.org/10.1023/A:1009806403194

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