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Microwave-enhanced transition metal-catalyzed decoration of 2(1H)-pyrazinone scaffolds

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Abstract

The 2(1H)-pyrazinones have been demonstrated to be versatile building blocks for the synthesis of biologically active compounds. Here, an efficient method is described for the decoration of these interesting scaffolds. Microwave-assisted palladium catalyzed reactions allow the easy introduction of different substituents at the C3- and even at the rather unreactive C5-position of the pyrazinones. Stille, Suzuki, Heck, Sonogashira reactions, in addition to reductive dechlorinations, and cyanation reactions are investigated.

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Authors and Affiliations

  1. Laboratory for Organic Synthesis, Department of Chemistry, University of Leuven, Leuven, Belgium

    Nadya Kaval, Katalin Bisztray, Wim Dehaen & Erik Van der Eycken

  2. Institute of Chemistry, Karl-Franzens-University Graz, Graz, Austria

    C. Oliver Kappe

Authors
  1. Nadya Kaval
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  2. Katalin Bisztray
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  3. Wim Dehaen
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  4. C. Oliver Kappe
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  5. Erik Van der Eycken
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Correspondence to Erik Van der Eycken.

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Kaval, N., Bisztray, K., Dehaen, W. et al. Microwave-enhanced transition metal-catalyzed decoration of 2(1H)-pyrazinone scaffolds. Mol Divers 7, 125–134 (2003). https://doi.org/10.1023/B:MODI.0000006807.43408.d5

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  • DOI: https://doi.org/10.1023/B:MODI.0000006807.43408.d5

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