Abstract
Solid Lipid Nanoparticles (SLNs) have been prepared fromc-2,c-8,c-14,c-20-tetraundecyl-4,6,10,12,16,18,22,24-octahydroxyresorc[4]areneas colloidal suspensions. Photon Correlation Spectroscopy studies revealed aparticle hydrodynamic diameter of 150 nm. Non-contact mode Atomic ForceMicroscopy allows observation of the particles as slightly flattened sphericalobjects of 236 (±40) nm diameter and 145 (±40) nm height. Thestudy of the preparation parameters showed that shear force does not affectthe hydrodynamic size of the SLNs. In contrast, the viscosity and the pH ofthe aqueous phase, the amphiphile concentration in the organic phase and thevolume of organic phase used, all lead to variation in the size of the particles.In term of post preparation parameters only the ionic strength has been shownto affect significantly the particle size; while the pH of the storing solution,microwave, ultrasonic and thermal treatments do not. Short and long-termstability studies have been performed to measure the effect of the ionic strengthon the stability of the particles. The use of carbohydrate cryoprotectants does notallow re-dispersion of the colloidal suspension after freeze-drying.
Similar content being viewed by others
References
Y. Kakizawa and K. Kataoka: Adv. Drug Deliv. Rev. 54, 203 (2002).
R. Banerjee and J. Biomater: Applications 16, 3 (2001).
J.U. Otaigbe, M.D. Barnes, K. Fukui, B.G. Sumpter, and D.W. Noid: Adv. Polym. Sci. 154, 1 (2001).
J.G. Weers: Curr. Opin. Colloid Interface Sci. 3, 540 (1998).
R.H. Muller, K. Mader, and S. Gohla: Eur. J. Pharm. Biopharm. 50, 161 (2000).
M. Demirel and Y. Yazan: J. Pharm. Sci. 25, 167 (2000).
M.A. Schubert and C.C. Muller-Goymann: Eur. J. Pharm. Biopharm. 55, 125 (2003).
S.-J. Lim and C.-K. Kim: Int. J. Pharm. 243, 135 (2002).
J.-X. Wang, X. Sun, and Z.-R. Zhang: Eur. J. Pharm. Biopharm. 54, 285 (2002).
C. Olbrich, A. Gessner, O. Kayser, and R.H. Muller: J. Drug Targeting 10, 387 (2002).
V. Jenning, A. Gysler, M. Schafer-Korting, and S.H. Gohla: Eur. J. Pharm. Biopharm. 49, 211 (2000).
C.S. Maia, W. Mehnert, and M. Schafer-Korting: Int. J. Pharm. 196, 165 (2000).
S.C. Yang, L.F. Lu, Y. Cai, J.B. Zhu, B.W. Liang, and C.Z. Yang: J. Controlled Release 59, 299 (1999).
R.H. Muller and S.A. Runge: Drug Targeting Deliv. 9, 219 (1998).
R.H. Muller: Proceed. Intl. Symp. Controlled Release Bioactive Materials 188 (2000).
A. Dubes, H. Parrot-Lopez, P. Shahgaldian, and A.W. Coleman: J. Colloid Interface Sci., in press (2003).
E. Perrier, N. Terry, N. Rival, and A.W. Coleman: French Patent FR20006102 (2000).
A. Dubes: Ph.D. thesis, University Claude Bernard Lyon I, Synthèses et études physico-chimiques de nouvelles cyclodextrines amphiphiles polyanioniques (2002).
T. Irie, M. Otagiri, M. Sunada, K. Uekama, Y. Ohtani, Y. Yamada, and Y. Sugiyama, J.: Pharmacobio-Dynamics 5, 741 (1982).
J. Szetjli: Cyclodextrin Technology, Kluwer Academic, Dordrecht, The Netherlands (1988).
P. Shahgaldian, M. Cesario, P. Goreloff, and A.W. Coleman: J. Chem. Soc. Chem. Commun. 326 (2002).
P. Shahgaldian, E. Da Silva, A.W. Coleman, B. Rather, and M.J. Zaworotko: Int. J. Pharm. 7348, 1 (2002).
P. Shahgaldian, L. Quattrocchi, J. Gualbert, A.W. Coleman, and P. Goreloff: Eur. J. Pharm. Biopharm. 55, 107 (2003).
P. Shahgaldian, J. Gualbert, K. Aissa, and A.W. Coleman: Eur. J. Pharm. Biopharm. 55, 181 (2003).
P. Shahgaldian, E. Da Silva, and A.W. Coleman: J. Incl. Phenom., Submitted for publication (2003).
E. Houel, A. Lazar, E. Da Silva, A.W. Coleman, A. Solovyov, S. Cherenok, V.I. Kalchenko: Langmuir 18, 1374 (2002).
J. Gualbert, P. Shahgaldian, and A.W. Coleman: Int. J. Pharm. 257, 69 (2003).
F. Perret, P. Shahgaldian, M. Mazzorana, and A.W. Coleman: First steps in the study of calix-arene toxicity, ISSC XI, Fukuoka, Japan (2000).
M.H.B.G. Gansey, A.S. De Haan, E.S. Bos, W. Verboom, and D.N. Reinhoudt: Conjugation, Bioconjugate Chemistry 10, 613 (1999).
P. Prus, M. Pietraszkiewicz, and R. Bilewicz: Materials Sci. Eng. C18, 157 (2001).
M. Pietraszkiewicz, P. Prus, and R. Bilewicz: Pol. J. Chem. 73, 2035 (1999).
K. Kurihara, K. Ohto, Y. Tanaka, Y. Aoyama, and T. Kunitake: J. Am. Chem. Soc. 113, 444 (1991).
O. Hayashida, K. Mizuki, K. Akagi, A. Matsuo, T. Kanamori, T. Nakai, and S. Sando, Y. Aoyama: J. Am. Chem. Soc. 125, 594 (2003).
Y. Tanaka, M. Mayachi, and Y. Kobuke: Angew. Chem., Int. Ed. 38, 504 (1999).
A. Dubes, H. Parrot-Lopez, W. Abdelwahed, G. Degobert, H. Fessi, P. Shahgaldian, and A. W. Coleman: Eur. J. Pharm. Biopharm. in press (2003).
L. Abis, E. Dalcanale, A. Du Vosel, and S. Spera: J. Org. Chem. 53, 5475 (1988).
F. Sommer, D. Tran Minh, A.W. Coleman, M. Skiba, and D. Wouessidjewe: Supramol. Chem. 3, 19 (1993).
M.H. Paclet, A.W. Coleman, S. Vergnaud, and F. Morel: Biochemistry 39, 9302 (2000).
N. Scholer, C. Olbrich, K. Tabatt, R.H. Muller, H. Hahn, and O. Liesenfeld: Int. J. Pharm. 221, 57 (2001).
D. Quintanar-Guerrero, H. Fessi, E. Alleman, and E. Doelker: Int. J. Pharm. 143, 133 (1996).
F. Franks: Water a Comprehensive Treatise, Vol. 2, Plenum Press, London (1973).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Gualbert, J., Shahgaldian, P., Lazar, A. et al. Solid Lipid Nanoparticles (SLNs): Preparation and Properties of Calix[4]resorcinarene Derived Systems.. Journal of Inclusion Phenomena 48, 37–44 (2004). https://doi.org/10.1023/B:JIPH.0000016598.29935.6e
Issue Date:
DOI: https://doi.org/10.1023/B:JIPH.0000016598.29935.6e