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Transient Expression of MDR-1/P-Glycoprotein in a Model of Partial Cortical Devascularization

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Abstract

1. MDR-1 gene product confer to expressing cells the multidrug resistance phenotype to a broad range of drugs and xenobiotics.

2. It is known that different stress signals are able to induce MDR-1 expression through different promoters.

3. In a rat model of ischemia by partial cortical devascularization we studied the expression profile and the cellular localization of MDR-1 after 1, 3, 7, 14 and 28 days post lesion (DPL).

4. Using two different antibody clones we found that MDR-1 is expressed in cortical and striatal neurons ipsilateral to the devascularizing lesion, starting at 1DPL, showing a maximum at 7DPL to be thereafter reduced until undetectable levels by 28DPL.

5. MDR-1 expression may be defining a neuronal subset with a particular pharmacological profile.

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Authors and Affiliations

  1. Facultad de Ciencias Biomédicas, Universidad Austral, Pilar, Buenos Aires, Argentina

    Alberto Javier Ramos (Prof. E. De Robertis” Facultad de Medicina) & Marcelo J. Villar

  2. Instituto de Biología Celular y Neurociencia, Universidad de Buenos Aires, Paraguay 2155, 1121, Buenos Aires, Argentina

    Alberto Javier Ramos (Prof. E. De Robertis” Facultad de Medicina), Alberto Lazarowski & Alicia Brusco

Authors
  1. Alberto Javier Ramos
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  2. Alberto Lazarowski
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  3. Marcelo J. Villar
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  4. Alicia Brusco
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Ramos, A.J., Lazarowski, A., Villar, M.J. et al. Transient Expression of MDR-1/P-Glycoprotein in a Model of Partial Cortical Devascularization. Cell Mol Neurobiol 24, 101–107 (2004). https://doi.org/10.1023/B:CEMN.0000012728.19117.73

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  • DOI: https://doi.org/10.1023/B:CEMN.0000012728.19117.73

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