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Microbeam developments and applications: A low linear energy transfer perspective

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Abstract

In the last few years there has been a significant increase in the number of centers having, or developing, both high- and low-linear energy transfer (LET) microbeams for radiobiological investigations. In this review, we will discuss the various approaches for developing low-LET single cell irradiation devices and consider the instrument designs and how the machines capabilities can be exploited to investigate targeted and non-targeted effects of low-LET irradiation.

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Authors and Affiliations

  1. Chemistry and Physics of Complex Systems, Pacific Northwest National Laboratory, MS K8-88, 3335 Q Ave, Richland, WA, 99352

    Marianne Sowa Resat

  2. Radiation Oncology Research Laboratory, BRB, 7-011, USA

    William F. Morgan

  3. Greenebaum Cancer Center, University of Maryland, Baltimore, MD, 21201-1551

    William F. Morgan

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  1. Marianne Sowa Resat
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  2. William F. Morgan
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Correspondence to Marianne Sowa Resat.

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Sowa Resat, M., Morgan, W.F. Microbeam developments and applications: A low linear energy transfer perspective. Cancer Metastasis Rev 23, 323–331 (2004). https://doi.org/10.1023/B:CANC.0000031770.96320.1e

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  • DOI: https://doi.org/10.1023/B:CANC.0000031770.96320.1e

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