Skip to main content
SpringerLink
Log in

Analysis of spinal cord proteome in the rats with mechanical allodynia after the spinal nerve injury

  • Published:
Biotechnology Letters Aims and scope Submit manuscript

Abstract

Proteome analysis was carried out to identify the proteins associated with neuropathic pain after peripheral nerve injury. Five proteins displayed different expression levels among three groups of rats. Among these proteins, creatine kinase B expression level was lower in the pain-positive rats compared to the sham or pain-negative rats. Therefore, a lower creatine kinase B expression level may be important in the development and maintenance of neuropathic pain.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Arawaka S, Daimon M, Sasaki H, Suzuki JI, Kato T (1998) A novel autoantibody in paraneoplastic sensory-dominant neuropathy reacts with brain-type creatine kinase. Int. J. Mol. Med. 1: 597–600.

    Google Scholar 

  • Brewer GJ, Wallimann TW (2000) Protective effect of the energy precursor creatine against toxicity of glutamate and beta-amyloid in rat hippocampal neurons. J. Neurochem. 74: 1968–1978.

    Google Scholar 

  • Chaplan SR, Bach FW, Pogrel JW, Chung JM, Yaksh TL (1994) Quantitative assessment of tactile allodynia in the rat paw. J. Neurosci. Meth. 53: 55–63.

    Google Scholar 

  • Dedeoglu A, Kubilus JK, Yang L, Ferrante KL, Hersch SM, Beal MF, Ferrante AR (2003) Creatine therapy provides neuroprotection after onset of clinical symptoms in Huntington's disease transgenic mice. J. Neurochem. 85: 1359–1367.

    Google Scholar 

  • Huang J, Shibata E, Kato K, Asaeda N, Takeuchi Y (1992) Chronic exposure to n-hexane induces changes in nerve-specific marker proteins in the distal peripheral nerve of the rat. Hum. Exp. Toxicol. 11: 323–327.

    Google Scholar 

  • Kim SH, Chung JM (1992) An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat. Pain 50: 355–363.

    Google Scholar 

  • Klivenyi P, Ferrante RJ, Matthews RT, Bogdanov MB, Klein AM, Andreassen OA, Mayer DJ, Mao J, Holt J, Price DD (1999) Cellular mechanisms of neuropathic pain, morphine tolerance, and their interactions. Proc. Natl. Acad. Sci. USA 96: 7731–7736.

    Google Scholar 

  • Matthews RT, Yang L, Jenkins BG, Ferrante RJ, Rosen BR, Kaddurah-Daouk R, Beal MF (1998) Neuroprotective effects of creatine and cyclocreatine in animal models of Huntington's disease. J. Neurosci. 18: 156–163.

    Google Scholar 

  • Mueller G, Wermer M, Kaddurah-Daouk R, Beal MF (1999) Neuroprotective effects of creatine in a transgenic animal model of amyotrophic lateral sclerosis. Nat. Med. 5: 347–350.

    Google Scholar 

  • Park S, Lee M, Kim HY, Jeoung DI (2002) Proteome analysis of 5-fluorouracil-resistance-associated protein in human gastric cancer cells. Biotechnol. Lett. 24: 1141–1145.

    Google Scholar 

  • Spruce MC, Potter J, Coppini DV (2003) The pathogenesis and management of painful diabetic neuropathy: a review. Diabet. Med. 20: 88–98.

    Google Scholar 

  • Sullivan PG, Geiger JD, Mattson MP, Scheff SW (2000) Dietary supplement creatine protects against traumatic brain injury. Ann. Neurol. 48: 723–729.

    Google Scholar 

  • Wallimann T, Wyss M, Brdiczka D, Nicolay K, Eppenberger HM (1992) Intracellular compartmentation, structure and function of creatine kinase isoenzymes in tissues with high and fluctuating energy demands: the phosphocreatine circuit for cellular energy homeostasis. Biochem. J. 281: 21–40.

    Google Scholar 

  • Wendt S, Dedeoglu A, Speer O, Wallimann T, Beal MF, Andreassen OA (2002) Reduced creatine kinase activity in transgenic amyotrophic lateral sclerosis mice. Free Radic. Biol. Med. 32: 920–926.

    Google Scholar 

  • Woolf CJ, Mannion RJ (1999) Neuropathic pain: aetiology, symptoms, mechanisms, and management. Lancet 353: 1959–1964.

    Google Scholar 

  • Ziegler EA, Magerl W, Meyer RA, Treede RD (1999) Secondary hyperalgesia to punctate mechanical stimuli. Central sensitization to A-fibre nociceptor input. Brain 122: 2245–2257.

    Google Scholar 

  • Zimmermann M (1983) Ethical guidelines for investigations of experimental pain in conscious animals. Pain 16: 109–110.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Anesthesiology, Seoul National University College of Medicine, Seoul, 110-744, Republic of Korea

    Sang Chul Lee & Tai Gyoon Yoon

  2. Cancer Genomics Division, In2Gen Company, Cancer Research Center, Cander Research Institute, National University College of Medicine, Seoul, 110-799, Republic of Korea

    Yong-Il Yoo

  3. National Research Laboratory for Cancer Epigentics, Cander Research Institute, National University College of Medicine, Seoul, 110-799, Republic of Korea

    Yung-Jue Bang

  4. College of Life Sciences, Kyung Hee University, Suwon, 449-701, Republic of Korea

    Hae-Yeong Kim

  5. Division of Life Sciences, Kangwon National University, Chunchon, 200-701, Republic of Korea

    Doo-Il Jeoung

  6. Department of Dental Anesthesiology and Dental Research Institute, Seoul National University College of Dentistry, Seoul, 110-744, Republic of Korea

    Hyun Jeong Kim

Authors
  1. Sang Chul Lee
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Tai Gyoon Yoon
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Yong-Il Yoo
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Yung-Jue Bang
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Hae-Yeong Kim
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Doo-Il Jeoung
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Hyun Jeong Kim
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Hyun Jeong Kim.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lee, S.C., Yoon, T.G., Yoo, YI. et al. Analysis of spinal cord proteome in the rats with mechanical allodynia after the spinal nerve injury. Biotechnology Letters 25, 2071–2078 (2003). https://doi.org/10.1023/B:BILE.0000007068.97472.89

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/B:BILE.0000007068.97472.89

Search

Navigation