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Glyprolines and Semax Prevent Stress-Induced Microcirculatory Disturbances in the Mesentery

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Abstract

One-hour immobilization stress considerably disturbed microcirculation in the mesentery: blood flow in small mesenteric vessels decreased or stopped and numerous hemorrhages appeared. Lymphatic vessels lost spontaneous activity and did not respond to norepinephrine. Administration of Semax and glyprolines 1 h before stress decreased the severity of stress-induced microcirculatory disturbances. PGP and GP were most effective in this respect.

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Authors and Affiliations

  1. Department of Human and Animal Physiology, Biological Faculty, M. V. Lomonosov Moscow State University, Russia

    G. N. Kopylova, E. A. Smirnova, L. Ts. Sanzhieva, B. A. Umarova, T. V. Lelekova & G. E. Samonina

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  1. G. N. Kopylova
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  2. E. A. Smirnova
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  3. L. Ts. Sanzhieva
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  4. B. A. Umarova
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  5. T. V. Lelekova
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  6. G. E. Samonina
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Kopylova, G.N., Smirnova, E.A., Sanzhieva, L.T. et al. Glyprolines and Semax Prevent Stress-Induced Microcirculatory Disturbances in the Mesentery. Bulletin of Experimental Biology and Medicine 136, 441–443 (2003). https://doi.org/10.1023/B:BEBM.0000017087.90585.a9

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  • DOI: https://doi.org/10.1023/B:BEBM.0000017087.90585.a9

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