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Levels of Hepatic Stimulator Substance in Liver Regenerating Process of Partially Hepatectomized Rats Pretreated with a Single Dose of Carbon Tetrachloride

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Abstract

Liver regeneration after injury with carbontetrachloride (CCl4) followed by partialhepatectomy is a complex model involving toxicological,inflammatory, and necrotic processes. In the presentstudy, the time-course of hepatic regenerative process wasinvestigated in relation to hepatic stimulator substance(HSS) activity, administration of a single dose ofCCl4 and partial (70%) hepatectomy in malerats. To evaluate liver injury events, the levels ofserum aspartic aminotransferase (AST), alanineaminotransferase (ALT), and alkaline phosphatase (ALP)were measured. Hepatic DNA synthesis reached a maximum at 36 hr after hepatectomy in contrast to thereported 24-hr and 32-hr peaks observed in nontreatedhepatectomized rats. On the other hand, HSS activityappeared to peak at 28, 40, and 44 hr after hepatectomy in CCl4-treated rats, and it wasquite a lot lower at 24, 32, 36, 48, and 60 hr. Thehypothesis that HSS promotes liver regeneration but itdoes not initiate it, as other factors have been foundto do, is discussed.

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Authors
  1. Aristotelis A. Liakos
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  2. Michael G. Mykoniatis
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  3. Marilena E. Kokala
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  4. Dimitrios G. Papadimitriou
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  5. George D. Liatsos
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Liakos, A.A., Mykoniatis, M.G., Kokala, M.E. et al. Levels of Hepatic Stimulator Substance in Liver Regenerating Process of Partially Hepatectomized Rats Pretreated with a Single Dose of Carbon Tetrachloride. Dig Dis Sci 44, 1046–1053 (1999). https://doi.org/10.1023/A:1026685319823

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