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Analytical Studies on the Role of Oxidants of the Olefinic Double Bond in the Determination of Flunarizine

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Abstract

Simple, sensitive, and selective spectrophotometric methods (M1 and M2) for the assay of flunarizine (FZ) through the olefinic double bond are proposed. Method M1 is based on the reaction of potassium permanganate to the olefinic double bond in FZ and estimating the unreacted permanganate with Fast Green FCF (FG FCF). Method M2 involves the treatment of the olefinic double bond in FZ with a Lemieux reagent (KMnO4 and NaIO4) and estimating the aldehyde formed with 3-methyl-2-benzothiazolinone hydrazone (MBTH). The color produced in both methods has maximum absorption at 620 nm. The Beer's law limits, precision, and accuracy of the methods are checked by the reference method. The methods are found to be suitable for the determination of flunarizine. The recoveries range from 99.18 to 101.13%.

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Authors and Affiliations

  1. Foods and Drugs Laboratories, School of Chemistry, India

    Adapa V. S. S. Prasad, Chilukuri S. P. Sastry & Viplava P. Uppuleti

  2. Department of Pharmaceutical Sciences, Andhra University, Visakhapatnam, 530003, India

    Chilukuri S. R. Lakshmi

Authors
  1. Adapa V. S. S. Prasad
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  2. Chilukuri S. R. Lakshmi
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  3. Chilukuri S. P. Sastry
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  4. Viplava P. Uppuleti
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Prasad, A.V.S.S., Lakshmi, C.S.R., Sastry, C.S.P. et al. Analytical Studies on the Role of Oxidants of the Olefinic Double Bond in the Determination of Flunarizine. Journal of Analytical Chemistry 58, 937–942 (2003). https://doi.org/10.1023/A:1026123632330

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  • DOI: https://doi.org/10.1023/A:1026123632330

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