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Expression of Prolactin Receptors in Human Liver during Cholestasis of Different Etiology and Secondary Liver Cancer

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Abstract

Indirect immunoperoxidase assay and computer analysis of photographic images revealed more intensive expression of prolactin receptors in hepatocytes of women compared to men. The intensity of expression was maximum in secondary liver cancer, high in obstructive jaundice of different etiology, and less pronounced in cholelithiasis. The expression of prolactin receptors in cholangiocytes was higher than in hepatocytes and was maximum during obstructive jaundice of different etiology. Cells of secondary tumors were characterized by low expression, while distant hepatocytes most intensively expressed prolactin receptors.

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REFERENCES

  1. I. V. Kovtun, A. N. Smirnov, B. V. Turovetskii, and O. V. Smirnova, Byull. Eksp. Biol. Med., 122,No. 8, 193-196 (1996).

    Google Scholar 

  2. A. N. Orlova, A. N. Smirnov, and O. V. Smirnova, Ibid., 127,No. 5, 573-575 (1999).

    Google Scholar 

  3. O. V. Smirnova, O. M. Petraschuk, and A. N. Smirnov, Ibid., 125,No. 1, 66-70 (1998).

    Google Scholar 

  4. C. Bole-Feysot, V. Goffin, M. Edery, et al., Endocr. Rev., 19, 225-268 (1998).

    Google Scholar 

  5. T. Garsia-Caballero, H. Mertani, A. Lambert, et al., Endocrine, 12, 265-271 (2000).

    Google Scholar 

  6. A. Hofmann, Liver, 22,Suppl. 2, 14-19 (2002).

    Google Scholar 

  7. S. Kloehn, C. Otte, M. Korsanke, et al., Horm. Metab. Res., 7, 394-401 (2001).

    Google Scholar 

  8. H. Kuper, C. Mantzoros, A. Tzonou, et al., Oncology, 60, 355-360 (2001).

    Google Scholar 

  9. D. Kuruppu, C. Christophi, J. Bertram, et al., J. Gastroenterol. Hepatol., 13, 521-527 (1998).

    Google Scholar 

  10. H. Okamura, J. Zachwieja, S. Raguet, et al., Endocrinology, 124, 2499-2508 (1989).

    Google Scholar 

  11. R. Piccoletti, P. Bendinelli, and P. Maroni, Mol. Cell. Endocrinol., 135, 169-177 (1997).

    Google Scholar 

  12. O. Smirnova, O. Petraschuk, and P. Kelly, Ibid., 105,No. 1, 77-81 (1994).

    Google Scholar 

  13. A. Smolen, Methods in Neuroscience. Qualitative and Quantitative Microscopy, 3, 208-229 (1990).

    Google Scholar 

  14. M. Strazzabosco, C. Spirli, and L. Okolicsanyi, J. Gastroenterol. Hepatol., 3, 244-253 (2000).

    Google Scholar 

  15. M. G. Swain, J. Hepatol., 35, 416-418 (2001).

    Google Scholar 

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Authors and Affiliations

  1. Laboratory of Endocrinology, Biological Faculty, M. V. Lomonosov Moscow State University, Russia

    T. Yu. Zenkova, A. V. Kulikov, R. L. Bogorad, A. A. Rozenkrants, L. V. Platonova, N. I. Shono, E. I. Gal'perin & O. V. Smirnova

  2. Laboratory of Molecular Genetics of Intracellular Transport, Institute of Gene Biology, Russian Academy of Sciences, Russia

    T. Yu. Zenkova, A. V. Kulikov, R. L. Bogorad, A. A. Rozenkrants, L. V. Platonova, N. I. Shono, E. I. Gal'perin & O. V. Smirnova

  3. Department of Biophysics, Biological Faculty, M. V. Lomonosov Moscow State University, Russia

    T. Yu. Zenkova, A. V. Kulikov, R. L. Bogorad, A. A. Rozenkrants, L. V. Platonova, N. I. Shono, E. I. Gal'perin, E. I. Gal'perin & O. V. Smirnova

  4. Department for Surgery of the Liver and Bile Ducts and Metabolic Surgery, I. M. Sechenov Moscow Medical Academy, Russia

    T. Yu. Zenkova, A. V. Kulikov, R. L. Bogorad, A. A. Rozenkrants, L. V. Platonova, N. I. Shono & O. V. Smirnova

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  1. T. Yu. Zenkova
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  2. A. V. Kulikov
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  3. R. L. Bogorad
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  4. A. A. Rozenkrants
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  5. L. V. Platonova
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  6. N. I. Shono
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  7. E. I. Gal'perin
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  8. O. V. Smirnova
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Corresponding author

Correspondence to O. V. Smirnova.

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Zenkova, T.Y., Kulikov, A.V., Bogorad, R.L. et al. Expression of Prolactin Receptors in Human Liver during Cholestasis of Different Etiology and Secondary Liver Cancer. Bulletin of Experimental Biology and Medicine 135, 566–569 (2003). https://doi.org/10.1023/A:1025429318932

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  • DOI: https://doi.org/10.1023/A:1025429318932

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