Abstract
Regarding sintered bodies of hydroxyapatite (HAP)/zirconia (PSZ) composite particles prepared by covering the surface of HAP particles with PSZ particles, their strength of the bond to bone after implanting them into an organism and their cytotoxicity were evaluated. Cytotoxicity tests were conducted by the colony formation method. Cytotoxicity was not observed in the sintered bodies of HAP/PSZ composite particles, or in sintered monolithic HAP body and sintered monolithic PSZ body. The strength of bond between a sintered body and a bone was evaluated by measuring the shear strength at the interface between them after a fixed period following implantation of a sintered body into a rabbit femur. In all cases of the sintered monolithic HAP body, and the sintered bodies of HAP/PSZ composite particles and monolithic PSZ body, when the implantation period increased, the shear strength of the sintered body/bone interface tended to increase. In particular, this tendency was very high in the case of sintered bodies of HAP/PSZ with weight ratios of 1/1.0 and 1/1.5, the shear strength for each reaching 20 MPa 12 months after implantation.
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References
A. Sawa, J. Jpn. Soc. Biomater. 12 (1994) 73.
P. Kumar, M. Oka, K. Ikeuchi, K. Shimizu, T. Yamamuro, H. Okumura and Y. Kotoura, J. Biomed. Mater. Res. 25 (1991) 813.
Y. Yokogawa, M. Toriyama, Y. Kawamoto, T. Suzuki and S. Kawamura, J. Ceram. Sci. Japan 100 (1992) 602.
A. Hasegawa, T. Kameyama, A. Motoe, M. Ueda, K. Akashi and K. Fukuda, ibid. 100 (1992) 377.
K. Ioku, M. Yoshimura and S. Somiya, Biomaterials 11 (1990) 57.
J. Li, L. Hermansson and R. Söremark, J. Mater. Sci. Mater. Med. 4 (1993) 50.
M. Takagi, M. Mochida, N. Uchida, K. Saito and K. Uematsu, ibid. 3 (1992) 199.
N. Tamari, I. Kondo, M. Mouri and M. Kinoshita, J. Ceram. Soc. Japan 96 (1988) 1200.
C. Huang, Z. Zhang and Z. Tang, J. Mater. Sci. Lett. 18 (1999) 1815.
N. Tamari, M. Mouri and I. Kondo, Yogyo-Kyokai-Shi 95 (1987) 806.
K. Ioku, S. Somiya and M. Yoshimura, J. Ceram. Soc. Japan 99 (1991) 196.
Y. Yamada and R. Watanabe, ibid. 103 (1995) 1264.
J. Li, H. Liao and L. Hermansson, Biomaterials 17 (1996) 1787.
R. B. Heimann and T. A. Vu, J. Mater. Sci. Lett. 16 (1997) 437.
H. Honda, M. Kimura, T. Matsuno and M. Koishi, Chimicaoggi 9 (1991) 21.
H. Honda, M. Kimura, T. Matsuno and M. Koishi, Colloids Surfaces A: Physicochem. Eng. Aspects 82 (1994) 117.
T. Matsuno, K. Watanabe, K. Ono and M. Koishi, J. Ceram. Soc. Japan 104 (1996) 945.
N. Kawashima, K. Soetanto, K. Watanabe, K. Ono and T. Matsuno, Colloids Surfaces B: Biointerfaces 10 (1997) 23.
T. Matsuno, K. Watanabe, K. Ono and M. Koishi, J. Mater. Sci. Lett. 19 (2000) 573.
S. Wakuri, J. Izumi, K. Sasaki, N. Tanaka and H. Ono, Toxic. in vitro 7 (1993) 517.
T. Tsuchiya, T. Arai, J. Ohhashi, K. Imai, H. Kojima, S. Miyamoto, H. Hata, Y. Ikarashi, K. Toyoda, M. Takahashi and A. Nakamura, J. Biomed. Mater. Res. 27 (1993) 885.
N. Takeshita, S. Kiniwa, T. Ono, K. Hayashi, T. Kurozumi, K. Takanashi, Y. Kuwana, Y. Yamanaka and N. Nagai, J. Implant 7 (1986) 71.
S. Ohtuka, J. Jpn. Soc. Biomater. 7 (1989) 59.
T. Nonami and N. Satoh, J. Ceram. Soc. Japan 103 (1995) 804.
M. Niki, J. Jpn. Soc. Biomater. 12 (1994) 5.
M. Fukuda, Jpn. J. Oral. Maxillofac. Surg. 38 (1992) 1718.
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Matsuno, T., Morita, M., Watanabe, K. et al. Strength of bond to bone and cytotoxicity of sintered bodies of hydroxyapatite/zirconia composite particles. Journal of Materials Science: Materials in Medicine 14, 547–555 (2003). https://doi.org/10.1023/A:1023464115384
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DOI: https://doi.org/10.1023/A:1023464115384