Skip to main content
SpringerLink
Log in

E1AF Expression Levels are not Associated with Prognosis in Human Breast Cancer

  • Published:
Breast Cancer Research and Treatment Aims and scope Submit manuscript

Abstract

E1AF is a transcription factor involved in regulation of several metastasis-associated genes, and is associated with overexpression of HER2/neu. We were unable to find a clear prognostic value of E1AF expression in human breast cancer. Furthermore, no association of E1AF levels with HER2/neu mRNA levels, hormone receptor status, histological grade, tumor size, or lymph node involvement was found.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Kaya M, Yoshida K, Higashino F, Mitaka T, Ishii S, Fujinaga K: A single ets-related transcription factor, E1AF, confers invasive phenotype on human cancer cells. Oncogene 12: 221–227, 1996

    Google Scholar 

  2. de Launoit Y, Chotteau-Lelievre A, Beaudoin C, Coutte L, Netzer S, Brenner C, Huvent I, Baert JL: The PEA3 group of ETS-related transcription factors. Role in breast cancer metastasis. Adv Exp Med Biol 480: 107–116, 2000

    Google Scholar 

  3. Benz CC, O'Hagan RC, Richter B, Scott GK, Chang CH, Xiong X, Chew K, Ljung BM, Edgerton S, Thor A, Hassell JA: HER2/neu and the Ets transcription activator PEA3 are coordinately upregulated in human breast cancer. Oncogene 15: 1513–1525, 1997

    Google Scholar 

  4. Shepherd TG, Kockeritz L, Szrajber MR, Muller WJ, Hassell JA: The pea3 subfamily ets genes are required for HER2/neumediated mammary oncogenesis. Curr Biol 11: 1739–1748, 2001

    Google Scholar 

  5. Xing X, Wang SC, Xia W, Zou Y, Shao R, Kwong KY, Yu Z, Zhang S, Miller S, Huang L, Hung MC: The ets protein PEA3 suppresses HER-2/neu overexpression and inhibits Tumorigenesis. Nat Med 6: 189–195, 2000

    Google Scholar 

  6. Wang SC, Zhang L, Hortobagyi GN, Hung MC: Targeting HER2: recent developments and future directions for breast cancer patients. Semin Oncol 28: 21–29, 2001

    Google Scholar 

  7. Harrell Jr FE, Lee KL, Matchar DB, Reichert TA: Regression models for prognostic prediction: advantages, problems, and suggested solutions. Cancer Treat Rep 69: 1071–1077, 1985

    Google Scholar 

  8. Span PN, Manders P, Heuvel JJTM, Thomas CMG, Bosch RR, Beex LVAM, Sweep CGJ: Expression of the transcription factor Ets-1 is an independent prognostic marker for relapsefree survival in breast cancer. Oncogene 21: 8506–8509, 2002

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Chemical Endocrinology, University Medical Center Nijmegen, Nijmegen, The Netherlands

    Paul N. Span, Peggy Manders, Joop J.T.M. Heuvel & C.G.J. (Fred) Sweep

  2. Department of Medical Oncology, University Medical Center Nijmegen, Nijmegen, The Netherlands

    Peggy Manders & Louk V.A.M. Beex

Authors
  1. Paul N. Span
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Peggy Manders
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Joop J.T.M. Heuvel
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Louk V.A.M. Beex
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. C.G.J. (Fred) Sweep
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Span, P.N., Manders, P., Heuvel, J.J. et al. E1AF Expression Levels are not Associated with Prognosis in Human Breast Cancer. Breast Cancer Res Treat 79, 129–131 (2003). https://doi.org/10.1023/A:1023338424677

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/A:1023338424677

Search

Navigation