Abstract
Kohonen's self-organization model, a neural network model, is applied to predict the β-turns in proteins. There are 455 β-turn tetrapeptides and 3807 non-β-turn tetrapeptides in the training database. The rates of correct prediction for the 110 β-turn tetrapeptides and 30,229 non-β-turn tetrapeptides in the testing database are 81.8% and 90.7%, respectively. The high quality of prediction of neural network model implies that the residue-coupled effect along a polypeptide chain is important for the formation of reversal turns, such as β-turns, during the process of protein folding.
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Cai, YD., Yu, H. & Chou, KC. Prediction of β-Turns. J Protein Chem 17, 363–376 (1998). https://doi.org/10.1023/A:1022559300504
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DOI: https://doi.org/10.1023/A:1022559300504