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Pyridoxal 5"-Phosphate as a Catalytic and Conformational Cofactor of Muscle Glycogen Phosphorylase b

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Abstract

This review summarizes data on structure of muscle glycogen phosphorylase b and the role of the cofactor pyridoxal 5"-phosphate in catalysis and stabilizing the native conformation of the enzyme. Specific attention is paid to the stabilizing role of pyridoxal 5"-phosphate upon denaturation of phosphorylase b. Stability of holoenzyme, apoenzyme, and enzyme reduced by sodium borohydride is compared.

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REFERENCES

  1. Parnas, J. K., and Baranowski, T. (1935) Compt. Rend. Soc. Biol., 120, 307–311.

    Google Scholar 

  2. Cori, C. F., and Cori, G. T. (1936) Proc. Soc. Exp. Biol. Med., 34, 202–205.

    Google Scholar 

  3. Cori, G. T., Colowick, S. P., and Cori, C. F. (1938) J. Biol. Chem., 123, 381–389.

    Google Scholar 

  4. Cori, G. T., and Cori, C. F. (1945) J. Biol. Chem., 158, 324–332.

    Google Scholar 

  5. Madsen, N. B., and Cori, C. F. (1956) J. Biol. Chem., 223, 1055–1066.

    Google Scholar 

  6. Wang, J. H., Shonka, M. L., and Graves, D. J. (1965) Biochemistry, 4, 2296–2301.

    Google Scholar 

  7. Krebs, E. G., and Fischer, E. H. (1956) Biochim. Biophys. Acta, 20, 150–156.

    Google Scholar 

  8. Graves, D. J., and Wang, J. H. (1972) in The Enzymes (Boyer, P. D., ed.) Vol. 7, Academic Press, New York, pp. 435–482.

    Google Scholar 

  9. Dombradi, V. (1981) Int. J. Biochem., 13, 125–139.

    Google Scholar 

  10. Oikonomakos, N. G., Acharya, K. R., and Johnson, L. N. (1992) in Post–translational Modifications of Proteins (Harding, J. J., and Grabbe, M. J. C., eds.) CRC Press, Boca Raton, pp. 81–150.

    Google Scholar 

  11. Kurganov, B. I. (1995) in Proteins and Peptides (Ivanov, V. T., and Lipkin, V. M., eds.) Nauka, Moscow, pp. 109–117.

    Google Scholar 

  12. Livanova, N. B., and Kornilaev, B. A. (1996) Biochemistry (Moscow), 61, 1432–1442.

    Google Scholar 

  13. Morgan, H. E., and Parmeggiani, A. (1964) J. Biol. Chem., 239, 2440–2445.

    Google Scholar 

  14. Okazaki, T., Nakazawa, A., and Hayashi, O. (1968) J. Biol. Chem., 243, 5266–5271.

    Google Scholar 

  15. Silonova, G. V., and Lisovskaya, N. P. (1967) Doklady AN SSSR, 174, 718–721.

    Google Scholar 

  16. Klinov, S. V., Chebotareva, N. A., Kurganov, B. I., Litvak, Zh. I., Zhilina, T. A., Glebova, G. D., Pekel, N. D., and Beresovskii, V. M. (1984) Bioorg. Khim., 10, 1161–1170.

    Google Scholar 

  17. Cori, G. T., Colowick, S. P., and Cori, C. F. (1939) J. Biol. Chem., 127, 771–782.

    Google Scholar 

  18. Kasvinsky, P. J., Madsen, N. B., and Fletterick, R. J. (1978) J. Biol. Chem., 253, 1290–1296.

    Google Scholar 

  19. Cohen, P., Duewer, T., and Fischer, E. H. (1971) Biochemistry, 10, 2683–2694.

    Google Scholar 

  20. Silonova, G. V., and Kurganov, B. I. (1970) Mol. Biol. (Moscow), 4, 445–459.

    Google Scholar 

  21. Feldmann, K., Zeisel, H., and Helmreich, E. (1972) Proc. Natl. Acad. Sci. USA, 69, 2278–2282.

    Google Scholar 

  22. Titani, K., Koide, A., Hermann, J., Ericsson, L. H., Kumar, S., Wade, R. D., Walsh, K. A., Neurath, H., and Fischer, E. H. (1977) Proc. Natl. Acad. Sci. USA, 74, 4762–4766.

    Google Scholar 

  23. Nakano, K., Hwang, P. K., and Fletteric, R. J. (1986) FEBS Lett., 204, 283–287.

    Google Scholar 

  24. Barford, D., and Johnson, L. N. (1992) Protein Sci., 1, 472–493.

    Google Scholar 

  25. Johnson, G. F., Tu, J. I., Bartlett, M. L., and Graves, D. J. (1970) J. Biol. Chem., 245, 5560–5568.

    Google Scholar 

  26. Johnson, L. N., and Barford, D. (1990) J. Biol. Chem., 265, 2409–2412.

    Google Scholar 

  27. Barford, D., and Johnson, L. N. (1989) Nature, 340, 609–616.

    Google Scholar 

  28. Kasvinsky, P. J., Shechosky, S., and Fletterick, R. J. (1978) J. Biol. Chem., 253, 9102–9106.

    Google Scholar 

  29. Sprang, S., Fletterick, R., Stern, M., Yang, D., Madsen, N. B., and Sturtevant, J. (1982) Biochemistry, 21, 2036–2048.

    Google Scholar 

  30. Meyer, F., Heilmeyer, L. M. G., Jr., Haschke, R. H., and Fischer, E. H. (1970) J. Biol. Chem., 245, 6642–6648.

    Google Scholar 

  31. Helmreich, E., Michaelides, M. C., and Cori, C. F. (1967) Biochemistry, 6, 3695–3710.

    Google Scholar 

  32. Baranowski, T., Illingworth, B., Brown, D. H., and Cori, C. F. (1957) Biochim. Biophys. Acta, 25, 16–21.

    Google Scholar 

  33. Helmreich, E. J. M. (1992) BioFactors, 3, 159–172.

    Google Scholar 

  34. Braunstein, A. E., and Shemyakin, M. M. (1952) Doklady AN SSSR, 85, 1115–1118.

    Google Scholar 

  35. Braunstein, A. E., and Shemyakin, M. M. (1953) Biokhimiya, 18, 393–411.

    Google Scholar 

  36. Braunstein, A. E. (1973) The Enzymes (Boyer, P. D., ed.) Vol. 9, Academic Press, N. Y., pp. 379–481.

    Google Scholar 

  37. Snell, E. E. (1958) Vitamins and Hormones, 16, 77–125.

    Google Scholar 

  38. Fisher, E. H., Kent, A., Snyder, E., and Krebs, E. G. (1958) J. Am. Chem. Soc., 80, 2906.

    Google Scholar 

  39. Hedrick, J. L., Shaltiel, S., and Fischer, E. H. (1966) Biochemistry, 5, 2117–2125.

    Google Scholar 

  40. Feldman, K., Zeisel, H., and Helmreich, E. J. M. (1976) Eur. J. Biochem., 65, 285–291.

    Google Scholar 

  41. Shaltiel, S., Hedrick, J. L., Pocker, A., and Fischer, E. H. (1969) Biochemistry, 8, 5189–5196.

    Google Scholar 

  42. Graves, D. J., Parrish, R. F., Uhing, R. J., and Korytnyk, W. (1976) in Regulatory Mechanism of Carbohydrate Metabolism (Essmann, V., ed.) Pergamon Press, Oxford, pp. 195–204.

    Google Scholar 

  43. Parrish, R. F., Uhing, R. J., and Graves, D. J. (1977) Biochemistry, 16, 4824–4831.

    Google Scholar 

  44. Chang, Y. C., McCalmont, T., and Graves, D. J. (1983) Biochemistry, 22, 4987–4993.

    Google Scholar 

  45. Johnson, L. N., Hajdu, J., Acharya, K. R., Stuart, D. I., McLaughlin, P. I., and Barford, D. (1989) in Allosteric Enzymes (Herve, G., ed.) CRC Press, Boca Raton, pp. 81–127.

    Google Scholar 

  46. Helmreich, E., and Cori, C. F. (1964) Proc. Natl. Acad. Sci. USA, 51, 131–138.

    Google Scholar 

  47. Kastenschmidt, L. L., Kastenschmidt, J., and Helmreich, E. (1968) Biochemistry, 7, 4543–4556.

    Google Scholar 

  48. Feldmann, K., and Hull, W. E. (1977) Proc. Natl. Acad. Sci. USA, 74, 836–860.

    Google Scholar 

  49. Feldmann, K., Hörl, M., Klein, H. W., and Helmreich, E. J. M. (1978) Proc. FEBS, 42, 205–218.

    Google Scholar 

  50. Helmreich, E. J. M., and Klein, H. W. (1980) Angew. Chem. Int. Ed. Engl., 19, 441–455.

    Google Scholar 

  51. Palm, D., Klein, H. W., Schinzel, R., Buehner, M., and Helmreich, E. J. M. (1990) Biochemistry, 29, 1099–1106.

    Google Scholar 

  52. Lisovskaya, N. P., and Silonova, G. V. (1970) Biokhimiya, 35, 448–457.

    Google Scholar 

  53. Kurganov, B. I., Klinov, S. V., and Chebotareva, N. A. (1994) Uspekhi Biol. Khim., 34, 83–110.

    Google Scholar 

  54. Chebotareva, N. A., Klinov, S. V., and Kurganov, B. I. (2001) Biotech. Genet. Eng. Rev., 18, 265–297.

    Google Scholar 

  55. Cori, C. F., and Illingworth, B. (1957) Proc. Natl. Acad. Sci. USA, 43, 547–552.

    Google Scholar 

  56. Shaltiel, Sh., Hedrick, J. L., and Fischer, E. H. (1966) Biochemistry, 5, 2108–2116.

    Google Scholar 

  57. Chebotareva, N. A., Sugrobova, N. P., Bulanova, L. N., Poznanskaya, A. A., Kurganov, B. I., and Gunar, V. I. (1995) Biochemistry (Moscow), 60, 1551–1558.

    Google Scholar 

  58. Gunar, V. I., Sugrobova, N. P., Chebotareva, N. A., Stepanova, S. V., Poznanskaya, A. A., and Kurganov, B. I. (1990) in Enzymes Dependent on Pyridoxal Phosphate and Other Carbonyl Compounds as Cofactors (Fukui, T., Kagamiyama, H., Soda, K., and Wada, H., eds.) Pergamon Press, Oxford, pp. 417–419.

    Google Scholar 

  59. Chebotareva, N. A., Sugrobova, N. P., Poznanskaya, A. A., Bulanova, L. N., Lyubarev, A. E., and Gunar, V. I. (1994) Doklady AN SSSR, 335, 255–257.

    Google Scholar 

  60. Weisshaar, H. D., and Palm, D. (1972) Biochemistry, 11, 2146–2154.

    Google Scholar 

  61. Avramovic–Zikic, O., Smillie, L. B., and Madsen, N. B. (1970) J. Biol. Chem., 245, 1558–1565.

    Google Scholar 

  62. Chebotareva, N. A., Kurganov, B. I., Lyubarev, A. E., Davidov, D. R., and Pekel, N. D. (1991) Biochimie, 73, 1329–1343.

    Google Scholar 

  63. Kurganov, B. I., Kornilaev, B. A., Chebotareva, N. A., Malikov, V. P., Orlov, V. N., Lyubarev, A. E., and Livanova, N. B. (2000) Biochemistry, 39, 13144–13152.

    Google Scholar 

  64. Kornilaev, B. A., Kurganov, B. I., Eronina, T. B., and Livanova, N. B. (1996) Biochemistry (Moscow), 61, 628–634.

    Google Scholar 

  65. Kornilaev, B. A., Kurganov, B. I., Eronina, T. B., Chebotareva, N. A., Livanova, N. B., Orlov, V. N., and Chernyak, V. Ya. (1997) Mol. Biol. (Moscow), 31, 98–107.

    Google Scholar 

  66. Kornilaev, B. A., Kurganov, B. I., Livanova, N. B., Eronina, T. B., Orlov, V. N., Chernyak, V. Ya., and Poglazov, B. F. (1997) Doklady RAN, 352, 256–258.

    Google Scholar 

  67. DeVincenzi, D. L., and Hedrick, J. L. (1970) Biochemistry, 9, 2048–2058.

    Google Scholar 

  68. Eronina, T. B., Chebotareva, N. A., Livanova, N. B., and Kurganov, B. I. (2001) Biochemistry (Moscow), 66, 449–455.

    Google Scholar 

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Authors and Affiliations

  1. Bach Institute of Biochemistry, Russian Academy of Sciences, Leninskii pr. 33, Moscow, 119071, Russia

    N. B. Livanova, N. A. Chebotareva, T. B. Eronina & B. I. Kurganov

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  1. N. B. Livanova
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  2. N. A. Chebotareva
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  3. T. B. Eronina
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  4. B. I. Kurganov
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Correspondence to N. B. Livanova.

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Livanova, N.B., Chebotareva, N.A., Eronina, T.B. et al. Pyridoxal 5"-Phosphate as a Catalytic and Conformational Cofactor of Muscle Glycogen Phosphorylase b . Biochemistry (Moscow) 67, 1089–1098 (2002). https://doi.org/10.1023/A:1020978825802

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