Abstract
The lecture summarizes data on the structural and pharmacological properties of KCNQ channels, in particular KCNQ2-5, associated primarily with the nervous system. The KCNQ channels are known to play a crucial role in the control of neuronal excitability. Two classes of drugs altering KCNQ channel activity and therefore producing considerable changes in neuronal excitability are described. These are KCNQ/M channel blocking agents (linopirdine, TEA) and KCNQ channel enhancers (retigabine).
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Brown, D.A., Selyanko, A.A., Hadley, J.K. et al. Some Pharmacological Properties Of Neural KCNQ Channels. Neurophysiology 34, 91–94 (2002). https://doi.org/10.1023/A:1020768914645
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DOI: https://doi.org/10.1023/A:1020768914645