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Brain Stem GABA Receptor Functional Regulation During Rat Liver Cell Proliferation

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Abstract

GABAergic alterations in brain stem during compensatory hyperplasia after partial hepatectomy (PH), lead nitrate (LN)-induced direct hyperplasia, and N-nitrosodiethylamine (NDEA)-induced neoplasia in liver were investigated. GABA content decreased in brain stem of PH- and NDEA-treated rats while it increased in LN-treated rats. GABAA receptor number and affinity in brain stem membrane preparations of rats showed a significant decrease in PH- and NDEA-treated rats. The GABAB receptor number increased in PH- and NDEA-treated rats with an increase in affinity. The results of the present study indicate that liver cell proliferation is influencing the brain stem GABAergic neurotransmission and these changes regulate the hepatic proliferation through the sympathetic stimulation.

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Authors and Affiliations

  1. Molecular Neurobiology and Cell Biology Unit, Centre for Neuroscience, Department of Biotechnology, Cochin University of Science and Technology, Cochin, 682 022, India

    Mangatt P. Biju, Sulaiman Pyroja & Cheramadathikudyil S. Paulose

  2. Amala Cancer Research Centre, Amala Nagar P. O. Thrissur, 680553, Kerala, India

    Neelimmathara V. Rajeshkumar

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  1. Mangatt P. Biju
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  3. Neelimmathara V. Rajeshkumar
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  4. Cheramadathikudyil S. Paulose
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Biju, M.P., Pyroja, S., Rajeshkumar, N.V. et al. Brain Stem GABA Receptor Functional Regulation During Rat Liver Cell Proliferation. Neurochem Res 27, 905–910 (2002). https://doi.org/10.1023/A:1020391514995

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