Abstract
Of 17 organic phases, some containing one of the five extractants for solvent extraction of lactic acid from Rhizopus arrhizus broth, solvents containing tertiary amines (Hostarex A327, trioctylamine) and secondary amine with isotridecanol modifier and trihexylphosphate, are from point of view of toxicity suitable for the in situ or on-line extraction. Pentaphosphinedipentylester is highly toxic. Toxicity of alcohols used as modifiers, decreases with an increase in the number of carbons in a molecule. Isotridecanol is medium toxic. Octanol and isodecanol and solvents containing them are toxic.
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Martak, J., Sabolova, E., Schlosser, S. et al. Toxicity of organic solvents used in situ in fermentation of lactic acid by Rhizopus arrhizus. Biotechnology Techniques 11, 71–75 (1997). https://doi.org/10.1023/A:1018408220465
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DOI: https://doi.org/10.1023/A:1018408220465