Skip to main content
SpringerLink
Log in

Improved Delivery Through Biological Membranes. XVII. A Site-Specific Chemical Delivery System as a Short-Acting Mydriatic Agent

  • Published:
Pharmaceutical Research Aims and scope Submit manuscript

Abstract

O,O-Di(ethylsuccinyl) adrenalone was synthesized and studied as a potential short-acting mydriatic agent. This unsymmetrical tetraester has a very short hydrolytic half-life in biological fluids (approximately 1 minute). The hydrolysis produces the inactive adrenalone. On the other hand, a reduction-hydrolytic sequence resulting in adrenaline was established as the mechanism of action of these types of compounds. The facile activation to epinephrine and fast deactivation to adrenalone of the unreduced chemical delivery system results in a short-acting mydriatic agent, a potentially important diagnostic or surgical agent.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Brewster, M. E., Bodor, N. (1983) J. Parenteral Sci. Techn. 37, 159.

    Google Scholar 

  2. Bodor, N., Kaminski, J., Roller, R. (1978) Int. J. Pharmaceutics 1, 189–196.

    Google Scholar 

  3. Weekers, R., Delmarcelle, Y., Gastin, J. (1955) Am. J. Ophthalmol. 40, 666–672.

    Google Scholar 

  4. Hussain, A., Truelove, J. (1976) J. Pharm. Sci. 65 (10), 1510–1512.

    Google Scholar 

  5. McClure, D. (1975) in Prodrugs as Novel Drug Delivery Systems ACS Symposium Series (Higuchi, T. and Stella, V., eds.), 14, pp. 224–235. American Chemical Society, Washington, DC.

    Google Scholar 

  6. Bodor, N., Visor, G. (1984) Expt. Eye Res., in print.

  7. Freeman, J., Gettelfinger, T. (1981) Am. Intra-Ocular Implant Soc. J. 7, 172–173.

    Google Scholar 

  8. Schonberg, S. S., Ellis, P. P. (1969) Arch. Ophthalmol. 82, 351–355.

    Google Scholar 

  9. Mandell, A. I., Kitabachi, A. E. (1978) Ophthalmology 85, 268–275.

    Google Scholar 

  10. Milstein, J. B., Fife, T. H. (1969) Biochemistry 8, 623–627.

    Google Scholar 

  11. Shichi, H., Nebert, D. (1980) in Extrahepatic Metabolism of Drugs and Other Foreign Compounds (Gram, T., ed.), pp. 333–363, S. P. Medical and Scientific Books, New York.

    Google Scholar 

  12. Das, N., Shichi, H. (1981) Expt. Eye Res. 33, 525–533.

    Google Scholar 

  13. Shichi, H. (1969) 8, 60–68.

Download references

Author information

Authors and Affiliations

  1. Box J-4, J. Hillis Miller Health Center, Gainesville, FL, 32610

    Nicholas Bodor

Authors
  1. Nicholas Bodor
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Gary Visor
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Bodor, N., Visor, G. Improved Delivery Through Biological Membranes. XVII. A Site-Specific Chemical Delivery System as a Short-Acting Mydriatic Agent. Pharm Res 1, 168–173 (1984). https://doi.org/10.1023/A:1016348624897

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/A:1016348624897

Keywords

Search

Navigation