Abstract
The temperature modulated differential scanning calorimetry (MDSC®) technique has been used to characterise the low frequency molecular mobility of indomethacin and maltitol just above their respective calorimetric glass transition temperatureT g. Analysis has been made using the concept of complex specific heat. Spectroscopic information are thus obtained through the temperature dependence of the isochronal real and imaginary parts C′ and C″. This gives access to the fragility index m and the stretched exponent β. The comparison with dielectric spectroscopy has been performed to check the coherence of spectroscopic information. Measurements on maltitol enable to demonstrate the useful complementarity of the technique when the low frequencies dielectric relaxations are occulted by the presence of conductors default.
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Carpentier, L., Bourgeois, L. & Descamps, M. Contribution of Temperature Modulated DSC® to the Study of the Molecular Mobility in Glass Forming Pharmaceutical Systems. Journal of Thermal Analysis and Calorimetry 68, 727–739 (2002). https://doi.org/10.1023/A:1016080928333
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DOI: https://doi.org/10.1023/A:1016080928333