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Sulfate Homeostasis. II. Influence of Chronic Aspirin Administration on Inorganic Sulfate in Humans

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Abstract

The purpose of the present investigation was to determine the effect of chronic aspirin administration on the serum concentration and renal clearance of inorganic sulfate in healthy volunteers. In a randomized crossover study, eight male subjects received either no treatment or 975 mg of enteric-coated aspirin three times daily for 8 days. Blood and urine samples were collected on the eighth day over a 7-hr period. Midpoint salicylic acid concentrations in serum varied between 55 and 182 µg/ml (mean concentration of 109 µg/ml). Serum inorganic sulfate concentrations demonstrated a small but significant decrease on the eighth day of aspirin administration but there was no apparent change in the renal clearance of sulfate. There were significant correlations between the renal clearances, urinary excretion rates, and serum concentrations of creatinine and sulfate, reflecting the dependence of sulfate homeostasis on renal function. The serum concentration and renal clearance of creatinine, sodium, potassium, calcium, magnesium, and phosphorus were unaffected by aspirin treatment.

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REFERENCES

  1. R. H. Demeio. In D. M. Greenway (ed.), Metabolic Pathways, 3rd ed., Academic Press, New York, 1975, pp. 287–357.

    Google Scholar 

  2. A. A. Farooqui and L. A. Horrocks. Mol. Cell. Biochem. 66:87–95 (1985).

    Google Scholar 

  3. F. A. Ofusu, G. J. Modi, and M. A. Blajchman. Biochem. J. 248:889–896 (1987).

    Google Scholar 

  4. J. M. Walenga, M. Petitou, M. Samama, J. Fareed, and J. Choay. Thromb. Res. 52:553–563 (1988).

    Google Scholar 

  5. W. B. Huttner. Topics Biol. Sci. 12:361–363 (1987).

    Google Scholar 

  6. G. J. Mulder. In G. J. Mulder (ed.), Sulfation of Drugs and Related Compounds, CRC Press, Boca Raton, FL, 1981, pp. 131–186.

    Google Scholar 

  7. F. Berglund. Acta Physiol. Scand. 49 (Suppl. 172):1–37 (1960).

    Google Scholar 

  8. E. L. Becker, H. O. Heinemann, K. Igarashi, J. E. Hodler, and H. Gershberg. J. Clin. Invest. 39:1909–1913 (1960).

    Google Scholar 

  9. M. E. Morris, O. Kwon, and I. L. Mansfield. J. Pharmacol. Exp. Ther. 244:945–949 (1988).

    Google Scholar 

  10. L. T. Wong, G. Solomanraj, and B. H. Thomas. Xenobiotica. 6:574–584 (1976).

    Google Scholar 

  11. B. H. Thomas, W. Zeitz, and B. B. Coldwell. J. Pharm. Sci. 9:1367–1370 (1974).

    Google Scholar 

  12. B. J. de Vries, W. B. van den Berg, and L. B. A. van de Putte Arth. Rheum. 28:922–929 (1985).

    Google Scholar 

  13. M. J. Palmoski and K. D. Brandt. Arth. Rheum. 26:994–1001 (1983).

    Google Scholar 

  14. B. J. de Vries, W. B. van den Berg, E. Vitters, and L. B. A. Van de Putte. J. Rheumatol. 13:686–693 (1986).

    Google Scholar 

  15. J. C. Lukas, T. S. Rosenkrantz, J. R. Raye, P. J. Porte, and A. F. Phillips. Am. J. Obstet. 156:245–249 (1987).

    Google Scholar 

  16. G. Turner and E. Collins. Lancet 2:338–339 (1975).

    Google Scholar 

  17. M. E. Morris and I. L. Mansfield. J. Pharm. Sci. 77:814–815 (1988).

    Google Scholar 

  18. H. Greiling and B. Schuler. Z. Rheumaforsch. 22:47–56 (1963).

    Google Scholar 

  19. G. Levy. J. Pharm. Sci. 54:959–967 (1965).

    Google Scholar 

  20. M. E. Morris and G. Levy. Anal. Biochem. 172:16–21 (1988).

    Google Scholar 

  21. K. R. Krijgsheld, E. Scholtens, and G. J. Mulder. Biochem. Pharmacol. 30:1973–1979 (1981).

    Google Scholar 

  22. Z. I. Sabry, S. B. Shadarevian, J. W. Cowan, and J. A. Campbell. Nature (Lond.) 206:931–933 (1965).

    Google Scholar 

  23. I. Smith and P. D. Mitchell. Biochem. J. 142:189–191 (1974).

    Google Scholar 

  24. M. E. Morris and G. Levy. J. Toxicol. Clin. Toxicol. 20:107–114 (1983).

    Google Scholar 

  25. M. Walser, D. W. Seldin, and A. Grollman. J. Clin. Invest. 32:299–311 (1953).

    Google Scholar 

  26. P. Lundquist, J. Mårtensson, B. Sörbo, and S. Öhman. Clin. Chem. 26:1178–1181 (1980).

    Google Scholar 

  27. M. E. Morris and G. Levy. Clin. Pharmacol. Ther. 33:529–536 (1983).

    Google Scholar 

  28. J. R. Leonards and G. Levy. JAMA 193:99–104 (1965).

    Google Scholar 

  29. J. H. Lin and G. Levy. J. Pharm. Sci. 72:213–217 (1983).

    Google Scholar 

  30. M. S. Meier and W. Schmidt-Kessen. Munch. med. Wschr. 120:357–362 (1978).

    Google Scholar 

  31. M. E. Morris, S. LeRoy, and S. C. Sutton. J. Toxicol. Clin. Toxicol. 25:371–382 (1987).

    Google Scholar 

  32. R. M. Freeman and C. J. Richards. Kidney Int. 15:167–175 (1979).

    Google Scholar 

  33. P. Kincaid-Smith. Drugs 32(Suppl. 4):109–128 (1986).

    Google Scholar 

  34. G. Levy. Drug Metab. Rev. 9:3–19 (1979).

    Google Scholar 

  35. E. J. Zambraski, D. C. Atkinson, and J. Diamond. J. Pharmacol. Exp. Ther. 247:96–103 (1988).

    Google Scholar 

  36. E. J. Zambraski, S. M. Guidotti, D. C. Atkinson, and J. Diamond. J. Pharmacol. Exp. Ther. 247:983–988 (1988).

    Google Scholar 

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Authors and Affiliations

  1. Department of Pharmaceutics, State University of New York at Buffalo, Amherst, New York, 14260

    Marilyn E. Morris & Lisa Jo Benincosa

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  1. Marilyn E. Morris
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  2. Lisa Jo Benincosa
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Morris, M.E., Benincosa, L.J. Sulfate Homeostasis. II. Influence of Chronic Aspirin Administration on Inorganic Sulfate in Humans. Pharm Res 7, 719–722 (1990). https://doi.org/10.1023/A:1015811504674

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