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Case Report: Regional Cerebral Hypoperfusion Induced by Ventricular Tachycardia – Short-term Hippocampal Hypoperfusion and its Potential Relationship to Selective Neuronal Damage

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Abstract

Background: Focussing on regional cerebral hypoperfusion during hemodynamically stable, but borderline hypotensive, sustained ventricular tachycardia (VT) experimental studies show (1) a reduction of cerebral blood flow (CBF) during tachyarrhythmias in contrast to the concept of CBF autoregulation, (2) a mediation of hypoperfusion by neuronal and humoral mechanisms, and (3) an involvment of microcirculation due to an ischemic stress response of the cerebral tissue. The clinical relevance of these observations remains still unclear.

Case reports: Two patients with coronary artery disease, left ventricular dysfunction and sustained monomorphic VT underwent electrophysiological study. VT was induced and the tracer 99mTc-HMPAO was injected after 3 minutes of ongoing VT. Regional CBF during this life threatening arrhythmia was determined with brain SPECT. A scanning protocol was performed after termination of VT. The measurements were repeated at baseline during normofrequent sinus rhythm (SR) one week later. CBF during SR was significantly reduced in the temporal lobe in comparison to the conditions during stable VT, particularly in the left hippocampus.

Conclusion: The reduction of hippocampal CBF due to cerebrovascular vasoconstriction and neuronal reflex mechanism previously observed in experiments during stable, sustained VT can be confirmed in a clinical scenario by high resolution 99mTc-HMPAO brain SPECT. This supports the hypothesis that repetitive stable VT can play a role in the pathophysiology of cerebrovascular insufficiency. Further clinical studies are needed to analyze the impact of tachyarrhythmias on cognitive and mnemic function.

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Author information

Authors and Affiliations

  1. Department of Cardiology, University of Leipzig, Leipzig, Germany

    Andreas Hagendorff & Dietrich Pfeiffer

  2. Department of Nuclear Medicine, University of Bonn, Bonn, Germany

    Edzard Klemm & Michael Bangard

  3. Institute of Neurological Rehabilitation, Hamburg, Germany

    Christian Dettmers

  4. Department of Cardiology, University of Mannheim, Mannheim, Germany

    Christian Wolpert

  5. Department of Cardiology, Fulda, Germany

    Burghard Schumacher

  6. Department of Nuclear Medicine, University of Bonn, Bonn, Germany

    Hans-J. Biersack & Frank Grünwald

  7. Department of Cardiology, University of Bonn, Bonn, Germany

    Berndt Lüderitz

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  1. Andreas Hagendorff
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  2. Edzard Klemm
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  4. Christian Dettmers
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  5. Christian Wolpert
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  10. Dietrich Pfeiffer
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Hagendorff, A., Klemm, E., Bangard, M. et al. Case Report: Regional Cerebral Hypoperfusion Induced by Ventricular Tachycardia – Short-term Hippocampal Hypoperfusion and its Potential Relationship to Selective Neuronal Damage. J Interv Card Electrophysiol 5, 435–441 (2001). https://doi.org/10.1023/A:1013202213276

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