Abstract
Electron microscopy showed signs of degenerative dystrophic changes in hepatocytes and structural decompensation of mitochondria in senescence-accelerated OXYS rats in comparison with Wistar rats. These signs were detected in the presence of liver mitochondria dysfunction in OXYS rats: reduced oxygen consumption rate in all metabolic states, respiratory control volume, ADP/O ratio. transmembrane potential, and phosphorylation rate. The revealed disorders in mitochondrial structure and function are the key factors in the pathogenesis of accelerated aging in OXYS rats and visceropathies characteristic of these animals.
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REFERENCES
N. G. Kolosova and A. R. Kolpakov, Biofizika, 36, No. 5, 802-804 (1991).
L. V. Loskutova and N. G. Kolosova, Byull. Eksp. Biol., 130, No. 8, 155-158 (2000).
L. M. Nepomnyashchikh, R. I. Salganik, G. I. Nepomnyashchikh, et al., Morphology of Genetically Determined and Common Pathological Processes in the Myocardium of W/ SSM Rats[in Russian], Novosibirsk (1995).
E. B. Men'shchikova, I. G. Shabalina, N. K. Zenkov, et al., Byull. SO Rossiisk. Akad. Med. Nauk, No. 3-4, 43-49 (2000).
R. I. Salganik, I. G. Shabalina, N. A. Solov.eva, et al., Byull. Eksp. Biol. Med., 119, No. 6, 628-631 (1995).
N. A. Solov'eva, T. S. Morozkova, and R. I. Salganik, Genetika, 11, No. 5, 63-71 (1975).
I. G. Shabalina, N. G. Kolosova, A. Yu. Grishanova, et al., Biokhimiya, 60, No. 12, 2045-2052 (1995).
P. M. Borodin, N. A. Solovyova, and O. V. Klotchkov, Rat News Lett., No. 1, 50-53 (1977).
E. Cadenas and K. J. A. Davies, Free Rad. Biol. Med., 29, No. 3-4, 222-230 (2000).
S. Desagher and J.-C. Martinou, Trends Cell. Biol., 10, 369-377 (2000).
C.-M. Kang, B. S. Kristal, and B. P. Yu, Free Rad. Biol. Med., 24, No. 1, 148-154 (1998).
H. Nohl, K. Staniek, and L. Gille, Exp. Gerontol., 32, No. 4-5, 485-500 (1997).
Rat Genome, 2, No. 2, 52-54 (1996).
R. I. Salganik, I. G. Shabalina, N. A. Solovyova, et al., Biochem. Biophys. Res. Commun., 205, No. 1, 180-185 (1994).
J. Sastre, A. Millan, J. G. de la Asuncion, et al., Free Rad. Biol. Med., 24, No. 2, 298-304 (1998).
M. K. Shigenaga, T. M. Hagen, and B. N. Ames, Proc. Natl. Acad. Sci. USA, 91, 10771-10778 (1994).
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Kolosova, N.G., Aidagulova, S.V., Nepomnyashchikh, G.I. et al. Dynamics of Structural and Functional Changes in Hepatocyte Mitochondria of Senescence-Accelerated OXYS Rats. Bulletin of Experimental Biology and Medicine 132, 814–819 (2001). https://doi.org/10.1023/A:1013014919721
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DOI: https://doi.org/10.1023/A:1013014919721