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Mouse Astrocytoma Models: Embryonic Stem Cell Mediated Transgenesis

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Abstract

The development of rational and targeted therapies for human astrocytomas is heavily dependent on our knowledge of its molecular pathogenesis, combined with the generation of appropriate pre-clinical mouse models. The ability to manipulate the mouse genome, which is nearing completion and is highly homologous to its human counterpart, has significantly accelerated our ability to create transgenic mouse models that replicate the pathological and molecular characteristics found in human astrocytomas. These models should serve to further our knowledge of the molecular pathogenesis of human astrocytomas, and serve as useful reagents to test conventional and novel thera-break peutics.

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Authors and Affiliations

  1. Mount Sinai Hospital, Samuel Lunenfeld Research Institute, Toronto, Ontario, Canada

    Hao Ding

  2. Arthur & Sonia Labatts Brain Tumor Center, Hospital for Sick Childrens Research Institute, Canada

    Abhijit Guha

  3. Division of Neurosurgery, The Toronto Hospital Western Division, University Health Network, Toronto, Ontario, Canada

    Abhijit Guha

Authors
  1. Hao Ding
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  2. Abhijit Guha
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Ding, H., Guha, A. Mouse Astrocytoma Models: Embryonic Stem Cell Mediated Transgenesis. J Neurooncol 53, 289–296 (2001). https://doi.org/10.1023/A:1012256230365

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  • DOI: https://doi.org/10.1023/A:1012256230365

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