REFERENCES
Simopoulos AP: Essential fatty acids in health and chronic disease. Am J Clin Nutr 70:560S–569S, 1999
Simopoulos AP, Leaf A, Salem N Jr.: Essentiality of and recommended dietary intakes for omega-6 and omega-3 fatty acids. Ann. Nutr. Metab. 43:127–130, 1999
Venkatraman JT, Chu W-C: Effects of dietary ω-3 and ω-6 lipids and vitamin E on proliferative response, lymphoid cell subsets, production of cytokines by spleen cells, and splenic protein levels for cytokines and oncogenes in MRL/MpJ-lpr/lpr mice. J Nutr Biochem 10:582–597, 1999
Venkatraman, JT, and Chu WC: Effects of dietary omega-3 and omega-6 lipids and vitamin E on serum cytokines, lipid mediators and anti-DNA antibodies in a mouse model for rheumatoid arthritis. J Am Coll Nutr 18:602–613, 1999
Lim BO, Jolly CA, Zaman K, Fernandes G: Dietary (n-6) and (n-3) fatty acids and energy restriction modulate mesenteric lymph node lymphocyte function in autoimmune-prone (NZB × NZW)F1 mice. J Nutr 130:1657–1664, 2000
Jolly CA, Fernandes G: Dietary n-3 fatty acids and calorie restriction in autoimmune disease: Influence in different immune compartments. Curr Org Chem 4:945–957, 2000
Grande JP, Donadio JV Jr: Dietary fish oil supplementation in IgA nephropathy: A therapy in search of a mechanism? [Editorial]. Nutrition 14:240–242, 1998
Grande JP, Walker HJ, Holub BJ, Warner GM, Keller DM, Haugen JD, Donadio JV Jr, Dousa TP: Suppressive effects of fish oil on mesangial cell proliferation in vitro and in vivo. Kidney Int 57:1027–1040, 2000
McMurray DN, Jolly CA, Chapkin RS: Effects of dietary n-3 fatty acids on T cell activation and T cell receptor-mediated signaling in a murine model. J Infect Dis 182:S103–S107, 2000
Hong MY, Lupton JR, Morris JS, Wang N, Carroll RJ, Davidson LA, Elder RH, Chapkin RS: Dietary fish oil reduces O6–methylguanine DNA adduct levels in rat colon in part by increasing apoptosis during tumor initiation [In Process Citation]. Cancer Epidemiol Biomark Prev 9:819–826, 2000
Fritsche KL, Byrge M, Feng C: Dietary omega-3 polyunsaturated fatty acids from fish oil reduce interleukin-12 and interferongamma production in mice. Immunol Lett 65:167–173, 1999
Feng C, Keisler DH, Fritsche KL: Dietary omega-3 polyunsaturated fatty acids reduce IFN-gamma receptor expression in mice [In Process Citation]. J Interferon Cytokine Res 19:41–48, 1999
Kremer JM, Lawrence DA, Jubiz W, DiGiacomo R, Rynes R, Bartholomew LE, Sherman M: Dietary fish oil and olive oil 100 supplementation in patients with rheumatoid arthritis. Clinical and immunologic effects. Arth Rheum 33:810–820, 1990
Kremer JM, Lawrence DA, Petrillo GF, Litts LL, Mullaly PM, Rynes RI, Stocker RP, Parhami N, Greenstein NS, Fuchs BR, Mathur A, Robinson DR, Sperling RI, Bigaouette J: Effects of high-dose fish oil on rheumatoid arthritis after stopping nonsteroidal antiinflammatory drugs. Clinical and immune correlates. Arth Rheum 38:1107–1114, 1995
Johnson MM, Swan DD, Surette ME, Stegner J, Chilton T, Fonteh AN, Chilton FH: Dietary supplementation with gamma-linolenic acid alters fatty acid content and eicosanoid production in healthy humans. J Nutr 127:1435–1444, 1997
Barham JB, Edens MB, Fonteh AN, Johnson MM, Easter L, Chilton FH: Addition of eicosapentaenoic acid to gamma-linolenic acid-supplemented diets prevents serum arachidonic acid accumulation in humans. J Nutr 130:1925–1931, 2000
Donadio JVJ, Bergstralh EJ, Offord KP, Spencer DC, Holley KE: A controlled trial of fish oil in IgA nephropathy. Mayo Nephrology Collaboratory Group. N Engl J Med 331:1194–1199, 1994
Donadio JV Jr: Use of fish oil to treat patients with immunoglobulin A nephropathy. Am J Clin Nutr 71:373S–375S, 2000
Alexander JW: Role of immunonutrition in reducing complications following organ transplantation. Transplant Proc 32:574–575, 2000
Gibson SW, Valente JF, Alexander JW, Custer DA, Li BG, Frede S, Babcock GF, Ogle CK: Nutritional immunomodulation leads to enhanced allograft survival in combination with cyclosporine A and rapamycin, but not FK506. Transplantation 69:2034–2038, 2000
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Kehn, P., Fernandes, G. The Importance of Omega-3 Fatty Acids in the Attenuation of Immune-Mediated Diseases. J Clin Immunol 21, 99–101 (2001). https://doi.org/10.1023/A:1011068108595
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DOI: https://doi.org/10.1023/A:1011068108595