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The Importance of Omega-3 Fatty Acids in the Attenuation of Immune-Mediated Diseases

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REFERENCES

  1. Simopoulos AP: Essential fatty acids in health and chronic disease. Am J Clin Nutr 70:560S–569S, 1999

    Google Scholar 

  2. Simopoulos AP, Leaf A, Salem N Jr.: Essentiality of and recommended dietary intakes for omega-6 and omega-3 fatty acids. Ann. Nutr. Metab. 43:127–130, 1999

    Google Scholar 

  3. Venkatraman JT, Chu W-C: Effects of dietary ω-3 and ω-6 lipids and vitamin E on proliferative response, lymphoid cell subsets, production of cytokines by spleen cells, and splenic protein levels for cytokines and oncogenes in MRL/MpJ-lpr/lpr mice. J Nutr Biochem 10:582–597, 1999

    Google Scholar 

  4. Venkatraman, JT, and Chu WC: Effects of dietary omega-3 and omega-6 lipids and vitamin E on serum cytokines, lipid mediators and anti-DNA antibodies in a mouse model for rheumatoid arthritis. J Am Coll Nutr 18:602–613, 1999

    Google Scholar 

  5. Lim BO, Jolly CA, Zaman K, Fernandes G: Dietary (n-6) and (n-3) fatty acids and energy restriction modulate mesenteric lymph node lymphocyte function in autoimmune-prone (NZB × NZW)F1 mice. J Nutr 130:1657–1664, 2000

    Google Scholar 

  6. Jolly CA, Fernandes G: Dietary n-3 fatty acids and calorie restriction in autoimmune disease: Influence in different immune compartments. Curr Org Chem 4:945–957, 2000

    Google Scholar 

  7. Grande JP, Donadio JV Jr: Dietary fish oil supplementation in IgA nephropathy: A therapy in search of a mechanism? [Editorial]. Nutrition 14:240–242, 1998

    Google Scholar 

  8. Grande JP, Walker HJ, Holub BJ, Warner GM, Keller DM, Haugen JD, Donadio JV Jr, Dousa TP: Suppressive effects of fish oil on mesangial cell proliferation in vitro and in vivo. Kidney Int 57:1027–1040, 2000

    Google Scholar 

  9. McMurray DN, Jolly CA, Chapkin RS: Effects of dietary n-3 fatty acids on T cell activation and T cell receptor-mediated signaling in a murine model. J Infect Dis 182:S103–S107, 2000

    Google Scholar 

  10. Hong MY, Lupton JR, Morris JS, Wang N, Carroll RJ, Davidson LA, Elder RH, Chapkin RS: Dietary fish oil reduces O6–methylguanine DNA adduct levels in rat colon in part by increasing apoptosis during tumor initiation [In Process Citation]. Cancer Epidemiol Biomark Prev 9:819–826, 2000

    Google Scholar 

  11. Fritsche KL, Byrge M, Feng C: Dietary omega-3 polyunsaturated fatty acids from fish oil reduce interleukin-12 and interferongamma production in mice. Immunol Lett 65:167–173, 1999

    Google Scholar 

  12. Feng C, Keisler DH, Fritsche KL: Dietary omega-3 polyunsaturated fatty acids reduce IFN-gamma receptor expression in mice [In Process Citation]. J Interferon Cytokine Res 19:41–48, 1999

    Google Scholar 

  13. Kremer JM, Lawrence DA, Jubiz W, DiGiacomo R, Rynes R, Bartholomew LE, Sherman M: Dietary fish oil and olive oil 100 supplementation in patients with rheumatoid arthritis. Clinical and immunologic effects. Arth Rheum 33:810–820, 1990

    Google Scholar 

  14. Kremer JM, Lawrence DA, Petrillo GF, Litts LL, Mullaly PM, Rynes RI, Stocker RP, Parhami N, Greenstein NS, Fuchs BR, Mathur A, Robinson DR, Sperling RI, Bigaouette J: Effects of high-dose fish oil on rheumatoid arthritis after stopping nonsteroidal antiinflammatory drugs. Clinical and immune correlates. Arth Rheum 38:1107–1114, 1995

    Google Scholar 

  15. Johnson MM, Swan DD, Surette ME, Stegner J, Chilton T, Fonteh AN, Chilton FH: Dietary supplementation with gamma-linolenic acid alters fatty acid content and eicosanoid production in healthy humans. J Nutr 127:1435–1444, 1997

    Google Scholar 

  16. Barham JB, Edens MB, Fonteh AN, Johnson MM, Easter L, Chilton FH: Addition of eicosapentaenoic acid to gamma-linolenic acid-supplemented diets prevents serum arachidonic acid accumulation in humans. J Nutr 130:1925–1931, 2000

    Google Scholar 

  17. Donadio JVJ, Bergstralh EJ, Offord KP, Spencer DC, Holley KE: A controlled trial of fish oil in IgA nephropathy. Mayo Nephrology Collaboratory Group. N Engl J Med 331:1194–1199, 1994

    Google Scholar 

  18. Donadio JV Jr: Use of fish oil to treat patients with immunoglobulin A nephropathy. Am J Clin Nutr 71:373S–375S, 2000

    Google Scholar 

  19. Alexander JW: Role of immunonutrition in reducing complications following organ transplantation. Transplant Proc 32:574–575, 2000

    Google Scholar 

  20. Gibson SW, Valente JF, Alexander JW, Custer DA, Li BG, Frede S, Babcock GF, Ogle CK: Nutritional immunomodulation leads to enhanced allograft survival in combination with cyclosporine A and rapamycin, but not FK506. Transplantation 69:2034–2038, 2000

    Google Scholar 

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Kehn, P., Fernandes, G. The Importance of Omega-3 Fatty Acids in the Attenuation of Immune-Mediated Diseases. J Clin Immunol 21, 99–101 (2001). https://doi.org/10.1023/A:1011068108595

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