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Parallel solution synthesis of pyridinethiones, pyridinones and thienopyridines

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Abstract

The parallel solution synthesis of three classes ofheterocycles is described. Arrays of pyridinethiones,pyridinones and thienopyridines were prepared usingone-step chemistry starting from readily accessiblebuilding blocks. The latter class of compounds wasaccessed by utilising a library-from-library approach.

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  10. As determined by HPLC at 215 nM.

  11. For product from entry 1, Scheme 2: 1H NMR (400 MHz, DMSO-d6) β 8.1 (2H, 2d), 7.7 (1H, dd), 7.5 (2H, 2dd), 6.9 (1H, s), 2.45 (3H, s), 2.1 (3H, s). M+1 for C16H14N2SO = 283.2 (calculated M+ = 282.37).

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Authors and Affiliations

  1. Biochem Pharma Inc., 275 Armand-Frappier Boulevard, Laval, Québec, Canada, H7V 4A7

    Stephen J. Shuttleworth, Miguel Quimpère, Nola Lee & Jeancarlo DeLuca

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  1. Stephen J. Shuttleworth
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  2. Miguel Quimpère
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  3. Nola Lee
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  4. Jeancarlo DeLuca
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Shuttleworth, S.J., Quimpère, M., Lee, N. et al. Parallel solution synthesis of pyridinethiones, pyridinones and thienopyridines. Mol Divers 4, 183–185 (1998). https://doi.org/10.1023/A:1009633311699

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