Abstract
One of the two overriding conditions for successfulBNCT is that there must be a sufficientnumber of thermal neutrons delivered to each ofthe boronated cells in the tumour bed (targetvolume). Despite the poor experience with BNCT inthe USA some 40 years ago, the continuedapparent success of BNCT in Japan since 1968,lead indirectly to the re-start of clinical trialson BNCT in 1994 at both Brookhaven andMIT. Similar trials will start soon at Pettenin Europe. At other centres worldwide, many neutronbeam designs are being proposed with either thermalor epithermal neutrons, emanating predominately from nuclear researchreactors. It is apparent that whilst the successof BNCT depends on a suitable neutron beam,there is a diversity in available designs, aswell as each proposed type of neutron source,with consequently different characteristics of the emergent neutronbeam. The paper presents the historical development ofneutron beams used for BNCT, addresses the requirementson the types of beams, describes some ofthe existing designs and other proposals elsewhere andlastly, considers the broader requirements in designing NCTfacilities. The focus of the paper is ontreatment of brain cancer, neutron beam requirements forother types of cancer may vary.
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References
Locher GL: Biological effects and therapeutic possibilities of neutrons. Am J Roentgenol 36: 1–13, 1936
Slatkin DN: A history of boron neutron capture therapy of brain tumors. Brain 114: 1609–1629, 1991
Hatanaka H et al.: Clinical experience of boron-neutron capture therapy for gliomas–a comparison with conventional chemo-immune-radiotherapy. In: Hatanaka H (ed) Boron-Neuron Capture Therapy for Tumors. Nishimura, Niigata, Japan 1986
Coderre JA: BNCT for malignant glioma using BPA. In: Mishima Y (ed) Proc. 6th Int. Symp. on Neutron Capture Therapy, Kobe, Japan, November 1994. Plenum Press, New York 1995
Madoc-Jones H, Zamenhof R, Solares R, Harling O: Clinical trial begins at MIT/NEMC. In: Mishima Y (ed) Proc. 6th Int. Symp. on Neutron Capture Therapy, Kobe, Japan, November 1994. Plenum Press, New York 1995
Fankhauser H: Proposed patient selection criteria and follow–up. In: Gabel D, Moss RL (eds) Boron Neutron Capture Therapy: Toward Clinical Trials of Glioma Treatment. Plenum Press, New York, 1992
Pöller F, Sauerwein W, Rassow J: Monte Carlo calculations of dose enhancement by neutron capture of 10B in fast neutron therapy. Phys Med Biol 38: 397–410, 1993
Allen DA, Beynon TD: A design study for an accelerator-based epithermal neutron beam for BNCT. Phys Med Biol 40: 807–821, 1995
Kim JK et al.: Californium-based epithermal neutron beams for neutron capture therapy. In: Soloway A et al. (eds) Advances in Neutron Capture Therapy. Plenum Press, New York, 1993
Farr LE et al.: Neutron capture therapy. In: Handbuch der Medizinische Radiologie. Springer, Heidelberg 1971
Farr LE et al.: Neutron capture therapy with boron in the treatment of glioblastoma multiforme. Am J Roentgenol 71: 279–293, 1954
Soloway AH et al.: Penetration of brain and brain tumor. VII. Tumor-binding sulfhydryl boron compounds. J Med Chem 10: 714–717, 1967
Kanda K: Development of neutron field for medial irradiation purposes. J At Energy Soc Japan 17: 582–586, 1975
Aizawa O et al.: Remodelling and dosimetry on the neutron irradiation facility of the Musashi Institute of Technology Reactor for boron neutron capture therapy. J Nucl Technol 48: 150–163, 1980
Nakagawa Y, Hatanaka H: Recent study of boron neutron capture therapy in patient with malignant tumor. In: Mishima Y (ed) Proc. 6th Int. Symp. on Neutron Capture Therapy, Kobe, Japan, November 1994. Plenum Press, New York 1995
Nakagawa Y et al.: Thermal neutron capture therapy for brain stem and skull base tumors: Heavy water and multiportal neutron delivery. In: Soloway A et al. (eds) Advances in Neutron Capture Therapy. Plenum Press, New York, 1993
Hatanaka H, Nakagawa Y: Clinical results of long-surviving brain tumor patients who underwent boron neutron capture therapy. Int J Rad Oncol Biol Phys 28 (5): 1061–1066, 1994
Mishima Y et al.: Treatment of malignant melanoma by single thermal neutron capture therapy with melanoma-seeking 10B-compound. Lancet 2: 388–389, 1989
Fairchild RG et al.: Clinical aspects of neutron capture therapy. In: Fairchild RG et al. (eds) Basic Life Sciences, vol 50. Plenum Press, New York, 1989
Yanch JC, Harling OK: A comparison of epithermal neutron beams for NCT: Effect of beam collimation on therapy parameters. In: Soloway A et al. (eds) Advances in Neutron Capture Therapy. Plenum Press, New York, 1993
Fairchild RG, Bond VP: Current status of 10B-neutron capture therapy: Enhancement of tumor dose via beam filtration and dose rate, and the effects of these parameters on minimum boron content: A theoretical evaluation. Int Rad Oncol Biol Phys 11: 831–840, 1985
Rhoades WA, Childs RL: Updated Version of DOT 4 One-and Two-Dimensional Neutron/Photon Transport Code. Oak Ridge National Laboratory, ORNL-5621, July 1980
Briesmeister JF (Ed): MCNP–A General Monte Carlo Code for Neutron and Photon Transport. LA-7596-M, Rev. 2, 1986
Fairchild RG et al.: An optimized epithermal neutron beam capture therapy (NCT) at the Brookhaven Medical Research Reactor (BMRR). In: Allen BJ (ed) Proc. on Neuron Capture Therapy for Cancer. Plenum Press, New York, 1992
Gabel DG: Goals of the European collaboration on boron neutron capture therapy. In: Allen BJ (ed) Proc. on Neutron Capture Therapy for Cancer. Plenum Press, New York, 1992
Moss RL et al.: Design, construction and installation of an epithermal neutron beam for BNCT at the High Flux Reactor at Petten. In: Allen BJ (ed) Proc. on Neutron Capture Therapy Cancer. Plnum Press, New York, 1992
Auterinen I, Hiismäki P: Construction of the epithermal BNCT station at the FiR 1. In: Mishima Y (ed) Proc. 6th Int. Symp. on Neutron Capture Therapy, Kobe, Japan, November 1994. Plenum Press, New York, 1995
Brugger R et al.: An epithermal neutron beam for neutron capture therapy at the Missouri University Research Reactor. J Nucl Tech 98 (3): 322–332, 1992
Nigg D, Storr G, Wheeler F: Physics parameters for an epithermal-neutron beam at the Georgia Institute of Technology. In: Soloway A et al. (eds) Advances in Neutron Capture Therapy. Plenum Press, New York, 1993
Rief H, Van Heusden R, Perlini G: Generating epithermal neutron beams for BNCT at TRIGA reactors. In: Soloway et al. (eds) Advances in Neutron Capture Therapy. Plenum Press, New York, 1993
Harling OK et al.: High intensity fission convertor based epithermal neutron beam for boron neutron capture therapy. In: Mishima Y (ed) Proc. 6th Int. Symp. on Neutron Capture Therapy, Kobe, Japan, November 1994. Plenum Press, New York, 1995
Liu B et al.: Design of a high flux epithermal neutron beam using 235U fission plates at the Brookhaven Medical Research Reactor. Med Phys 21: 1627–1631, 1994
Grusell E et al.: The possible use of a spallation source for neutron capture therapy with epithermal neutrons. In: Proc. of Neutron Beam Design, Development and Performance for Neutron Capture Therapy, Basic Life Sciences, vol 54. Plenum Press, New York, 1990
Yanch JC et al.: Accelerator-based epithermal neutron beams for neutron capture therapy. In: Soloway A et al. (eds) Advances in Neutron Capture Therapy. Plenum Press, New York, 1993
Rogus RD, Harling OK, Yanch JC: Mixed field dosimetry of epithermal neutron beams used for boron neutron capture therapy at the MIRT-II research reactor. Med Physics 21 (10): 1611–1625, 1994
Harling OK et al.: Head phantoms for neutron capture therapy. Med Physics 22 (5): 579–583, 1995
Moss RL, Siefert A, Watkins PRD, Constantine G, Philipp K: The Petten BNCT Facility: I–Phantom Dosimetry Techniques used in the Nuclear and Biological Characterisation of the Epithermal Neutron Beam and in the Halthy Tissue Tolerance Studies on the Canine Brain, and II–the Development towards a Treatment Planning System for the Treatment of Glioma Patients by BNCT. In: Harling O et al. (eds) Proc. Int. Workshop on Neutron Beam Design, Development and Performance for Neutron Capture Therapy, MIT Cambridge USA, March 1989, Basic Life Sciences, vol 54. Plenum Press, New York, 1990
Harling O et al. (eds) Neutron Beam Design, Development and Performance for Neutron Capture Therapy, MIT Cambridge USA, March 1989, Basic Life Sciences, vol 54. Plenum Press, 1990
Moss RL: Review of reactor-based neutron beam development for BNCT applications. In: Soloway A et al. (eds) Advances in Neutron Capture Therapy. Plenum Press, New York, 1993
Zamenhof R et al.: Federal and institutional approvals necessary prior to a U.S. clinical trial of neutron capture therapy. In: Soloway A et al. (eds) Advances in Neutron Capture Therapy. Plenum Press, New York, 1993
Kanda K: Procedures for the medical application of research reactors. In: Soloway A et al. (eds) Advances in Neutron Capture Therapy. Plenum Press, New York, 1993
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Moss, R., Aizawa, O., Beynon, D. et al. The requirements and development of neutron beams for neutron capture therapy of brain cancer. J Neurooncol 33, 27–40 (1997). https://doi.org/10.1023/A:1005704911264
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DOI: https://doi.org/10.1023/A:1005704911264