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Curdlan gels as protein drug delivery vehicles

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Abstract

The use of curdlan, a natural β-1,3-glucan, in protein drug delivery vehicles was studied by carrying out in vitro release studies with curdlan gels containing bovine serum albumin (BSA) as a model protein. Addition of urea (8 M) decreased the gel formation temperature to 37 °C. Curdlan was hydroxyethylated in order to form gels under mild conditions such as physiological temperature and pH. In gels formed in 8 M urea solution, urea was almost released after 2 h while BSA was completely released after 45–100 h. The total time for complete release of BSA increased with curdlan concentration within gels. The strength of hydroxyethylated curdlan gels (385.7 dyne cm−2) was weaker than that of curdlan gels formed in 8 M urea solution (6277 dyne cm−2).

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Authors and Affiliations

  1. Departments of Chemical Engineering, Korea

    Beom Soo Kim

  2. Chemistry, Korea

    In Duck Jung & Jong Sik Kim

  3. Biochemical Process Research Unit, Korea Research Institute of Bioscience and Biotechnology, Taejon, 305-600, Korea

    Jung-heon Lee & In Young Lee

  4. Biochemistry, College of Medicine, Konyang University, Nonsan, Chungnam, 320-711, Korea

    Kyung Bok Lee

Authors
  1. Beom Soo Kim
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  2. In Duck Jung
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  3. Jong Sik Kim
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  4. Jung-heon Lee
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  5. In Young Lee
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Kim, B.S., Jung, I.D., Kim, J.S. et al. Curdlan gels as protein drug delivery vehicles. Biotechnology Letters 22, 1127–1130 (2000). https://doi.org/10.1023/A:1005636205036

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  • DOI: https://doi.org/10.1023/A:1005636205036

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