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Production of artemisinin by hairy rot cultures of Artemisia annua L in bioreactor

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Abstract

Hairy root cultures of Artemisia annua L were cultivated in four different culture systems: a flask, a bubble column, a modified bubble column and a modified inner-loop airlift bioreactor. The artemisinin contents of hairy root cultures in the bubble column and the modified inner-loop airlift bioreactor were higher than that in the modified bubble column. The growth rate and hairy root distribution in the modified inner-loop airlift bioreactor were better than those in other bioreactors, and dry weight and artemisinin production reached to 26.8 g/L and 536 mg/L after 20 days.

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Authors and Affiliations

  1. State Key Laboratory of Biochemical Engineering , Institute of Chemical Metallurgy, Chinese Academy of Sciences, Beijing, 100080, China

    C.Z. Liu, Y.C. Wang & F. Ouyang

  2. Institute of Botany, Chinese Academy of Sciences, Beijing, 100093, China

    H.C. Ye & G.F. Li

Authors
  1. C.Z. Liu
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  2. Y.C. Wang
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  3. F. Ouyang
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  4. H.C. Ye
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  5. G.F. Li
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Liu, C., Wang, Y., Ouyang, F. et al. Production of artemisinin by hairy rot cultures of Artemisia annua L in bioreactor. Biotechnology Letters 20, 265–268 (1998). https://doi.org/10.1023/A:1005382020039

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  • DOI: https://doi.org/10.1023/A:1005382020039

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