Research ArticlesEncapsulation of lysozyme in a biodegradable polymer by precipitation with a vapor-over-liquid antisolvent
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Cited by (102)
Towards the development of a supercritical carbon dioxide spray process to coat solid protein particles
2018, Journal of Supercritical FluidsCitation Excerpt :In addition, via changes in the kinetics of CO2 depressurization, the particle morphology can be controlled to generate materials of variable density and surface roughness [25]. Protein encapsulation for controlled release using scCO2 has been investigated before [25–32]. In these studies, hydrophobic materials such as PLA, PLGA and lipids, were usually selected as the coating materials, and in some cases organic solvents were applied.
Low water-consumption technologies for textile production
2017, Sustainable Fibres and TextilesParticle formation and micronization using non-conventional techniques- review
2014, Chemical Engineering and Processing: Process IntensificationCitation Excerpt :Co-precipitation of the solutes and polymer occurred where composite microspheres or microcapsules were formed. Young et al. [11] investigated the lysozyme with a biodegradable polymer by precipitation with a vapor-over-liquid antisolvent, which is a modified precipitation with a compressed anti-solvent process. In their research, the vapor-over-liquid anti-solvent coating process was used to encapsulate lysozyme particles in a range of 1 μm–10 μm.
An overview on in situ micronization technique - An emerging novel concept in advanced drug delivery
2014, Saudi Pharmaceutical JournalCitation Excerpt :However, in the case of poorly soluble drugs, organic liquids are required that necessitate high machine expenditure (Reinhard, 2008). SCF technology is suitable for dissolution enhancement of drugs that are soluble in SCO2 like lysozyme particles (Young et al., 1999), nifedipine and lidocaine (Perrut et al., 2005a,b). Drugs that are not soluble in SCO2 are difficult to process through SCF technology.
Bacteria microencapsulation in PLGA microdevices by supercritical emulsion extraction
2012, Journal of Supercritical FluidsCitation Excerpt :Supercritical fluid technologies were also proposed to produce PLGA microdevices. Particularly, RESS technology showed problems of low solubility of almost all PLGA co-polymers in SC-CO2 that will prevent affordable process yields [28]; whereas, the even low solubility of SC-CO2 in the PLGA is again the main problem when using the SAS technology because it causes the precipitation of large polymer aggregates [29]. More recently, Bifidobacteria encapsulation into PVA/PVA complex matrix by supercritical fluid was also reported followed by a milling of the obtained complex [30].
PLGA microdevices for retinoids sustained release produced by supercritical emulsion extraction: Continuous versus batch operation layouts
2011, Journal of Pharmaceutical Sciences