Hostname: page-component-848d4c4894-4hhp2 Total loading time: 0 Render date: 2024-05-08T00:39:25.644Z Has data issue: false hasContentIssue false
  • English
  • Français

The role of anxiety in the integrative memory model

Published online by Cambridge University Press:  03 January 2020

Benjamin C. Nephew Open the ORCID record for Benjamin C. Nephew [Opens in a new window] ,
Serhiy Chumachenko Open the ORCID record for Serhiy Chumachenko [Opens in a new window]  and
Brent P. Forester
Benjamin C. Nephew
Affiliation:
Department of Biology and Biotechnology, Worcester Polytechnic Institute, Worcester, MA01609bcnephew@aol.comhttps://www.researchgate.net/profile/Benjamin_Nephew Department of Psychiatry, University of Massachusetts Medical School, Worcester, MA01655serhiy.chumachenko@umassmemorial.org
Serhiy Chumachenko
Affiliation:
Department of Psychiatry, University of Massachusetts Medical School, Worcester, MA01655serhiy.chumachenko@umassmemorial.org
Brent P. Forester
Affiliation:
Division of Geriatric Psychiatry, McLean Hospital, Belmont, MA02478. bforester@mclean.harvard.eduhttps://www.mcleanhospital.org/biography/brent-forester
Get access Rights & Permissions [Opens in a new window]

Abstract

We suggest that the inclusion of anxiety, as one relevant mood factor, could enhance the implementation of the integrative memory model in research and the clinic. The role of anxiety in Alzheimer's disease neuroanatomy, symptomology, and progression is used as an example. Customization of the integrative memory model can establish strong foundations for pathology-specific models of memory deficits, enhancing the development of precision medicine applications.

Type
Open Peer Commentary
Information
Behavioral and Brain Sciences , Volume 42 , 2019 , e293
Check for updates
Copyright
Copyright © Cambridge University Press 2020

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Donovan, N. J., Locascio, J. J., Marshall, G. A., Gatchel, J., Hanseeuw, B. J., Rentz, D. M., Johnson, K. A. & Sperling, R. A. (2018) Longitudinal association of amyloid beta and anxious-depressive symptoms in cognitively normal older adults. American Journal of Psychiatry 175(6):530–37. doi: 10.1176/appi.ajp.2017.17040442.CrossRefGoogle ScholarPubMed
Gallagher, D., Coen, R., Kilroy, D., Belinski, K., Bruce, I., Coakley, D., Walsh, B., Cunningham, C. & lawlor, B. A. (2011) Anxiety and behavioural disturbance as markers of prodromal Alzheimer's disease in patients with mild cognitive impairment. International Journal of Geriatric Psychiatry 26(2):166–72. doi:10.1002/gps.2509.CrossRefGoogle ScholarPubMed
Kaiser, N. C., Liang, L.-J., Melrose, R. J., Wilkins, S. S., Sultzer, D. L. & Mendez, M. F. (2014) Differences in anxiety among patients with early-versus late-onset Alzheimer's disease. The Journal of Neuropsychiatry and Clinical Neurosciences 26(1):73–80. doi:10.1176/appi.neuropsych.12100240.CrossRefGoogle ScholarPubMed
Maddock, R. J. & Buonocore, M. H. (1997) Activation of left posterior cingulate gyrus by the auditory presentation of threat-related words: An fMRI study. Psychiatry Research: Neuroimaging 75(1):1–14. doi:10.1016/S0925-4927(97)00018-8.CrossRefGoogle Scholar
Moulin, C. J. A., James, N., Perfect, T. J. & Jones, R. W. (2003) Knowing what you cannot recognise: Further evidence for intact metacognition in Alzheimer's disease. Aging, Neuropsychology, and Cognition 10(1):74–82. doi:10.1076/anec.10.1.74.13456.CrossRefGoogle Scholar
Piirainen, S., Youssef, A., Song, C., Kalueff, A. V., Landreth, G. E., Malm, T. & Tian, L. (2017) Psychosocial stress on neuroinflammation and cognitive dysfunctions in Alzheimer's disease: The emerging role for microglia? Neuroscience & Biobehavioral Reviews 77:148–64. doi:10.1016/j.neubiorev.2017.01.046.CrossRefGoogle ScholarPubMed
Ramakers, I. H. G. B., Verhey, F. R. J., Scheltens, P., Hampel, H., Soininen, H., Aalten, P., Rikkert, M. O., Verbeek, M. M., Spiru, L., Blennow, K., Trojanowski, J. Q., Shaw, L. M. & Visser, P. J. (2012) Anxiety is related to Alzheimer cerebrospinal fluid markers in subjects with mild cognitive impairment. Psychological Medicine 43(5):911–20. doi:10.1017/S0033291712001870.CrossRefGoogle ScholarPubMed
Reitz, C. (2016) Toward precision medicine in Alzheimer's disease. Annals of Translational Medicine 4(6):107. doi:10.21037/atm.2016.03.05.CrossRefGoogle ScholarPubMed
Russell-Williams, J., Jaroudi, W., Perich, T., Hoscheidt, S., El Haj, M. & Moustafa Ahmed, A. (2018) Mindfulness and meditation: Treating cognitive impairment and reducing stress in dementia. Reviews in the Neurosciences 29(7):791–804.CrossRefGoogle ScholarPubMed
Snitz, B. E., Weissfeld, L. A., Cohen, A. D., Lopez, O. L., Nebes, R. D., Aizenstein, H. J., McDade, E., Price, J. C., Mathis, C. A. & Klunk, W. E. (2015) Subjective cognitive complaints, personality and brain amyloid-beta in cognitively normal older adults. The American Journal of Geriatric Psychiatry 23(9):985–93. Available at: https://doi.org/10.1016/j.jagp.2015.01.008.CrossRefGoogle ScholarPubMed
Zhao, Q.-F., Tan, L., Wang, H.-F., Jiang, T., Tan, M.-S., Tan, L., Xu, W., Li, J.-Q., Wang, J., Lai, T.-J. & Yu, J.-T. (2016) The prevalence of neuropsychiatric symptoms in Alzheimer's disease: systematic review and meta-analysis. Journal of Affective Disorders 190:264–71. Available at: https://doi.org/10.1016/j.jad.2015.09.069.CrossRefGoogle ScholarPubMed
Zhao, X.-H., Wang, P.-J., Li, C.-B., Hu, Z.-H., Xi, Q., Wu, W.-Y. & Tang, X.-W. (2007) Altered default mode network activity in patient with anxiety disorders: An fMRI study. European Journal of Radiology 63(3):373–78. doi:10.1016/j.ejrad.2007.02.006.CrossRefGoogle Scholar