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Characterization of plasmids conferring resistance to gentamicin and apramycin in strains of Salmonella typhimurium phage type 204c isolated in Britain

Published online by Cambridge University Press:  19 October 2009

E. J. Threlfall ,
B. Rowe ,
J. L. Ferguson  and
L. R. Ward
E. J. Threlfall
Affiliation:
Division of Enteric Pathogens, Central Public Health Laboratory, 61 Colindale Avenue, London NW9 5HT
B. Rowe
Affiliation:
Division of Enteric Pathogens, Central Public Health Laboratory, 61 Colindale Avenue, London NW9 5HT
J. L. Ferguson
Affiliation:
Division of Enteric Pathogens, Central Public Health Laboratory, 61 Colindale Avenue, London NW9 5HT
L. R. Ward
Affiliation:
Division of Enteric Pathogens, Central Public Health Laboratory, 61 Colindale Avenue, London NW9 5HT
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In Salmonella typhimurium phage type 204c isolated in Britain, gentamicin resistance is specified by plasmids of the I1 compatibility group which also confer resistance to apramycin. These plasmids have been subdivided into three types within the I1 group on the basis of their antibiotic resistance specificity, their ability to produce colicin Ib and their restriction enzyme digest fragmentation patterns. All three have been identified in strains from cattle, but as yet only two types have been found in strains from humans.

It is suggested that the use of apramyein in animal husbandry is responsible for the appearance of gentamicin resistance in multiresistant strains of phage type 204 c, a phage type already epidemic in bovine animals and with an increasing incidence in humans.

Type
Research Article
Information
Journal of Hygiene , Volume 97 , Issue 3 , December 1986 , pp. 419 - 426
Copyright
Copyright © Cambridge University Press 1986

References

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