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Association of KRAS gene mutations with depression in older metastatic colorectal cancer patients

Published online by Cambridge University Press:  29 July 2016

Yi Zhou ,
Xiaohui Gu ,
Feng Wen ,
Jing Chen ,
Wen Wei ,
Zhi-Hui Zhang ,
Yanting He  and
Lan Xie
Yi Zhou
Affiliation:
The Department of Gynecology & Obstetrics, Hospital of the University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital, Chengdu, China
Xiaohui Gu
Affiliation:
Department of Geriatrics, Hospital of the University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital, Chengdu, China
Feng Wen
Affiliation:
The Department of Medical Oncology, Cancer Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China
Jing Chen
Affiliation:
Oncology Department, Sichuan Cancer Hospital, Chengdu, China
Wen Wei
Affiliation:
Oncology Department, Sichuan Cancer Hospital, Chengdu, China
Zhi-Hui Zhang
Affiliation:
Oncology Department, Sichuan Cancer Hospital, Chengdu, China
Yanting He
Affiliation:
The Department of Medical Oncology, Cancer Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China
Lan Xie*
Affiliation:
The Department of Gynecology & Obstetrics, Hospital of the University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital, Chengdu, China
*
Correspondence should be addressed to: Dr Lan Xie, The Department of Gynecology & Obstetrics, Hospital of the University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital, Chengdu, China. Phone: +86-28-87393999; Fax: +86-28-87393999. E-mail: 841423692@163.com.
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Abstract

Background:

Cancer patients with depression or anxiety have poor survival, and the interaction between mental and physical problems in older patients may exacerbate this problem. K-ras oncogene (KRAS) mutation may play a role in the development of psychosocial distress and may be associated with poor survival of metastatic colorectal cancer (mCRC) patients. This study investigated the association between KRAS gene mutations and psychosocial morbidity to explore the possible cancer/psychosis relationship in older mCRC patients.

Methods:

In this study, 62 newly diagnosed mCRC patients were recruited and completed the Hospital Anxiety and Depression Scale (HADS). Demographic data were also collected, and clinicopathological data were retrieved from medical records. KRAS mutations were assessed via PCR analysis of tissue specimens from the patients.

Results:

The results showed that 28 of the 62 participants (45.2%) had positive screens for possible depression, and 45 of the 62 participants (72.6%) had positive screens for anxiety. The KRAS mutation rate was 40.3% (25/62), and 19 of the 25 patients with KRAS mutations (76.0%) had probable depression, whereas only 24.3% of the patients with wild-type KRAS were probably depressed (p < 0.05). The KRAS mutation was associated with higher HADS depression scores, independent of gender and performance status (p < 0.05), but not with higher HADS anxiety or total scores.

Conclusions:

KRAS mutations were associated with depression severity and higher rates of probable depression in older mCRC patients. Depression should be assessed and treated as early as possible in older mCRC patients with the KRAS mutation. Further studies are needed to verify our current findings using a larger sample size.

Keywords

colorectal cancerdepressionKRASgene mutationgeriatrics
Type
Research Article
Information
International Psychogeriatrics , Volume 28 , Issue 12 , December 2016 , pp. 2019 - 2028
Copyright
Copyright © International Psychogeriatric Association 2016 

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